{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T15:49:16Z","timestamp":1758815356221},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,8,8]],"date-time":"2016-08-08T00:00:00Z","timestamp":1470614400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Pigmentation in mammals is important for protection of skin and eyes from ultraviolet radiation. Dysregulation of pigmentation is often associated with other conditions that are not directly linked to pigmentation. Here, we isolated spontaneously occurring hypopigmented mice that occasionally experienced severe diarrhea during lactation. Treatment of these mice with dextran sulfate sodium salt, a conventional method to induce acute colitis, caused chronic diarrhea with granulomatous colitis. Gene mapping and sequencing revealed that the mice had a nonsense mutation in the <jats:italic>Hermansky\u2013Pudlak syndrome (Hps)5<\/jats:italic> gene. As some HPS patients can develop granulomatous colitis, the simple induction of chronic colitis in spontaneously mutated <jats:italic>Hps5<\/jats:italic>\u2010deficient mice may become an invaluable model for exploring treatment options in patients with <jats:styled-content style=\"fixed-case\">HPS<\/jats:styled-content> as well as other patients with inflammatory bowel disease.<\/jats:p>","DOI":"10.1111\/pcmr.12504","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T21:06:35Z","timestamp":1466629595000},"page":"578-582","source":"Crossref","is-referenced-by-count":3,"title":["Simple chronic colitis model using hypopigmented mice with a <i>Hermansky\u2013Pudlak syndrome 5<\/i> gene mutation"],"prefix":"10.1111","volume":"29","author":[{"given":"Yumi","family":"Itoh","sequence":"first","affiliation":[{"name":"Cell Signaling and Metabolic Disease National Institute of Biomedical Innovation Ibaraki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Nagaoka","sequence":"additional","affiliation":[{"name":"Department of Life Science and Biotechnology Kansai University Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Katakura","sequence":"additional","affiliation":[{"name":"Department of Life Science and Biotechnology Kansai University Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidehisa","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Life Science and Biotechnology Kansai University Suita Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Takemori","sequence":"additional","affiliation":[{"name":"Cell Signaling and Metabolic Disease National Institute of Biomedical Innovation Ibaraki Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,8]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-09-671636"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00067.x"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.8.4.481"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPG.0b013e3181dc0d73"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12456"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201410026"},{"key":"e_1_2_4_8_1","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1182\/blood.V99.5.1651.h8001651_1651_1658","article-title":"The Hermansky\u2013Pudlak syndrome 1 (HPS1) and HPS2 genes independently contribute to the production and function of platelet dense granules, melanosomes, and lysosomes","volume":"99","author":"Feng L.","year":"2002","journal-title":"Blood"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-11-4398"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.02.005"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i12.888"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1318.2006.01046.x"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(02)00453-3"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12118"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2004.00208.x"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genom.9.081307.164303"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00858-X"},{"key":"e_1_2_4_18_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/genetics\/155.1.213","article-title":"Defective pigment granule biogenesis and aberrant behavior caused by mutations in the Drosophila AP\u20103beta adaptin gene ruby","volume":"155","author":"Kretzschmar D.","year":"2000","journal-title":"Genetics"},{"key":"e_1_2_4_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes5041095"},{"key":"e_1_2_4_20_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00024.2003"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3181fd2742"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2258"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaapos.2013.02.002"},{"key":"e_1_2_4_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000320279"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2000.130302.x"},{"key":"e_1_2_4_26_1","first-page":"552","article-title":"Perirectal abscess in the Hermansky\u2013Pudlak syndrome","volume":"84","author":"Sherman A.","year":"1989","journal-title":"Am. 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