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We describe the clinical course of a 15\u2010year\u2010old female diagnosed with <jats:styled-content style=\"fixed-case\">AJCC<\/jats:styled-content> stage <jats:styled-content style=\"fixed-case\">IB<\/jats:styled-content> non\u2010ulcerated primary melanoma, who died from metastatic disease 4\u00a0years after diagnosis despite three lines of modern systemic therapy. We also present the complete genomic profile of her tumour and compare this to a further series of 13 adolescent melanomas and 275 adult cutaneous melanomas. A somatic <jats:styled-content style=\"fixed-case\"><jats:italic>BRAF<\/jats:italic><jats:sup><jats:italic>V<\/jats:italic><\/jats:sup><\/jats:styled-content><jats:sup><jats:italic>600E<\/jats:italic><\/jats:sup> mutation and a high mutational load equivalent to that found in adult melanoma and composed primarily of C&gt;T mutations were observed. A germline genomic analysis alongside a series of 23 children and adolescents with melanoma revealed no mutations in known germline melanoma\u2010predisposing genes. Adolescent melanomas appear to have genomes that are as complex as those arising in adulthood and their clinical course can, as with adults, be unpredictable.<\/jats:p>","DOI":"10.1111\/pcmr.12574","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T03:29:37Z","timestamp":1484710177000},"page":"307-316","source":"Crossref","is-referenced-by-count":14,"title":["Genomic analysis and clinical management of adolescent cutaneous melanoma"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9195-5659","authenticated-orcid":false,"given":"Roy","family":"Rabbie","sequence":"first","affiliation":[{"name":"Experimental Cancer Genetics The Wellcome Trust Sanger Institute Hinxton Cambridgeshire UK"},{"name":"Department of Oncology Cambridge University Hospitals National Health Service Foundation Trust Cambridge 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