{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:12:55Z","timestamp":1788347575697,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,14]],"date-time":"2017-07-14T00:00:00Z","timestamp":1499990400000},"content-version":"vor","delay-in-days":194,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Development for Overcoming Diseases Project","award":["HI15C2404"],"award-info":[{"award-number":["HI15C2404"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Several studies observed that adiponectin, an important adipokine that improves glucose metabolism by regulating <jats:styled-content style=\"fixed-case\">AMP<\/jats:styled-content>\u2010activated protein kinase (<jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content>) signaling, is dermatologically beneficial. In our recent microarray data, we found that adiponectin expression was lower in lesional skin than in non\u2010lesional skin of melasma patients. Given that <jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content> is a key adiponectin signaling mediator, we investigated the role of adiponectin and <jats:styled-content style=\"fixed-case\">AICAR<\/jats:styled-content>, a cell\u2010permeable <jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content> activator, in melanogenesis. We herein showed that adiponectin and <jats:styled-content style=\"fixed-case\">AICAR<\/jats:styled-content> downregulated <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content>, tyrosinase, <jats:styled-content style=\"fixed-case\">TRP<\/jats:styled-content>\u20101, and <jats:styled-content style=\"fixed-case\">DCT<\/jats:styled-content> expression and reduced melanin content in normal human and mouse melanocytes. The depigmenting effect of adiponectin was mediated via <jats:styled-content style=\"fixed-case\">AMPK<\/jats:styled-content> activation, which induced the inhibitory phosphorylation of <jats:styled-content style=\"fixed-case\">CREB<\/jats:styled-content>\u2010regulated transcription co\u2010activators (<jats:styled-content style=\"fixed-case\">CRTC<\/jats:styled-content>s) and subsequent suppression of the novel <jats:styled-content style=\"fixed-case\">CRTC<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">CREB<\/jats:styled-content> pathway in melanocytes. These findings suggest that adiponectin and its analogs are useful as a clinical strategy for treating hyperpigmentation disorders.<\/jats:p>","DOI":"10.1111\/pcmr.12596","type":"journal-article","created":{"date-parts":[[2017,5,8]],"date-time":"2017-05-08T15:26:43Z","timestamp":1494257203000},"page":"553-557","source":"Crossref","is-referenced-by-count":45,"title":["Novel regulation of melanogenesis by adiponectin via the <scp>AMPK<\/scp>\/<scp>CRTC<\/scp> pathway"],"prefix":"10.1111","volume":"30","author":[{"given":"Seunghyun","family":"Bang","sequence":"first","affiliation":[{"name":"Department of Dermatology Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Hee","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye\u2010Rim","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanju","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Asan Institute for Life Sciences Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Areum","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Asan Institute for Life Sciences Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6268-5223","authenticated-orcid":false,"given":"Youngsup","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences Asan Institute for Life Sciences Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Eun","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asan Medical Center University of Ulsan College of Medicine  Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,14]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3072"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.185"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2000.130203.x"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365080"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2011.00871.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/ar4070"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3854-8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.04.028"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0005"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003816200"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.202"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12573"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M203719200"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.09.015"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1101739"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8687"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09564"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.12.034"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C000445200"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm788"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/dsu.12348"}],"container-title":["Pigment Cell &amp; 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