{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T03:32:50Z","timestamp":1788492770685,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,7,4]],"date-time":"2017-07-04T00:00:00Z","timestamp":1499126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005190","name":"Melanoma Research Alliance","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    To mitigate melanoma risk, sunscreen use is widely advocated; yet, the ability of sunscreens to prevent melanoma remains controversial. Here, we test the tenet that sunscreens limit melanoma risk by blocking ultraviolet radiation (\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    )\u2010induced\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    damage using murine models that recapitulate the genetics and spontaneous evolution of human melanoma. We find that a single, non\u2010erythematous dose of\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    dramatically accelerates melanoma onset and increases tumor multiplicity in mice carrying an endogenous, melanocyte\u2010specific\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content>\n                      as\n                    <\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>61R<\/jats:italic>\n                    <\/jats:sup>\n                    allele. By contrast, transient\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    exposure does not alter tumor onset in mice lacking p16\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:sup>INK<\/jats:sup>\n                    <\/jats:styled-content>\n                    <jats:sup>4a<\/jats:sup>\n                    or harboring an\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content>\n                      as\n                    <\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>12D<\/jats:italic>\n                    <\/jats:sup>\n                    allele. To block the rapid onset of melanoma cooperatively caused by\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    and\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">NR<\/jats:styled-content>\n                      as\n                    <\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>61R<\/jats:italic>\n                    <\/jats:sup>\n                    , we employed a variety of aerosol sunscreens. While all sunscreens delayed melanoma formation and blocked\n                    <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content>\n                    \u2010induced\n                    <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>\n                    damage, differences in aerosol output (i.e., amount applied\/cm\n                    <jats:sup>2<\/jats:sup>\n                    ) caused variability in the cancer preventative efficacy of products with identical sunburn protection factor (\n                    <jats:styled-content style=\"fixed-case\">SPF<\/jats:styled-content>\n                    ) ratings.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.12601","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T12:56:24Z","timestamp":1495716984000},"page":"477-487","source":"Crossref","is-referenced-by-count":37,"title":["Ultraviolet radiation accelerates\n                    <scp>NR<\/scp>\n                    as\u2010mutant melanomagenesis: A cooperative effect blocked by sunscreen"],"prefix":"10.1111","volume":"30","author":[{"given":"Rebecca C.","family":"Hennessey","sequence":"first","affiliation":[{"name":"Department of Cancer Biology and Genetics Biomedical Research Tower The Ohio State University  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea M.","family":"Holderbaum","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology and Genetics Biomedical Research Tower The Ohio State University  Columbus OH USA"},{"name":"Department of Molecular Genetics Biomedical Research Tower The Ohio State University  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anamaria","family":"Bonilla","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology and Genetics Biomedical Research Tower The Ohio State University  Columbus OH USA"},{"name":"Department of Molecular Genetics Biomedical Research Tower The Ohio State University  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conor","family":"Delaney","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology and Genetics Biomedical Research Tower The Ohio State University  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Gillahan","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology and Genetics Biomedical Research Tower The Ohio State University  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen L.","family":"Tober","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana M.","family":"Oberyszyn","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan H.","family":"Zippin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Joan and Sanford I. Weill Medical College of Cornell University  New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7919-3954","authenticated-orcid":false,"given":"Christin E.","family":"Burd","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology and Genetics Biomedical Research Tower The Ohio State University  Columbus OH USA"},{"name":"Department of Molecular Genetics Biomedical Research Tower The Ohio State University  Columbus OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,7,4]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"American Academy of Dermatology.What sunscreen should I use? In Sunscreen FAQs. 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