{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:19:23Z","timestamp":1787015963857,"version":"build-2736575974"},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,7,23]],"date-time":"2017-07-23T00:00:00Z","timestamp":1500768000000},"content-version":"vor","delay-in-days":203,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102014R1A2A2A09051812"],"award-info":[{"award-number":["NRF\u20102014R1A2A2A09051812"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2017,1]]},"abstract":"Summary<\/jats:title>\n \n Expression profiles revealed miR\u20101299 downregulation concomitant with arginase\u20102 (\n ARG<\/jats:styled-content>\n 2) upregulation in hyperpigmented skin of melasma patients. Opposite regulation of tyrosinase and\n PMEL<\/jats:styled-content>\n 17 by miR\u20101299 and inverse relationship between miR\u20101299 and\n ARG<\/jats:styled-content>\n 2 expression denoted a role of miR\u20101299 in pigmentation with\n ARG<\/jats:styled-content>\n 2 as a miR\u20101299 target.\n ARG<\/jats:styled-content>\n 2 overexpression or knock\u2010down in keratinocytes, the main source of\n ARG<\/jats:styled-content>\n 2 in epidermis, positively regulated tyrosinase and\n PMEL<\/jats:styled-content>\n 17 protein levels, but not\n mRNA<\/jats:styled-content>\n levels or melanosome transfer.\n ARG<\/jats:styled-content>\n 2 overexpression in keratinocytes reduced autophagy equivalent to 3\u2010\n MA<\/jats:styled-content>\n , an autophagy inhibitor which also increased tyrosinase and\n PMEL<\/jats:styled-content>\n 17 protein levels, whereas\n ARG<\/jats:styled-content>\n 2 knock\u2010down induced opposite results. Autophagy inducer rapamycin reduced\n ARG<\/jats:styled-content>\n 2\u2010increased tyrosinase and\n PMEL<\/jats:styled-content>\n 17 protein levels. Also, autophagy was reduced in late passage\u2010induced senescent keratinocytes showing\n ARG<\/jats:styled-content>\n 2 upregulation.\n ARG<\/jats:styled-content>\n 2, but not 3\u2010\n MA<\/jats:styled-content>\n , stimulated keratinocyte senescence. These results suggest that\n ARG<\/jats:styled-content>\n 2 reduces autophagy in keratinocytes by stimulating cellular senescence, resulting in skin pigmentation by reducing degradation of transferred melanosomes.\n <\/jats:p>","DOI":"10.1111\/pcmr.12605","type":"journal-article","created":{"date-parts":[[2017,6,19]],"date-time":"2017-06-19T02:29:07Z","timestamp":1497839347000},"page":"521-530","source":"Crossref","is-referenced-by-count":36,"title":["Arginase\u20102, a miR\u20101299 target, enhances pigmentation in melasma by reducing melanosome degradation via senescence\u2010induced autophagy inhibition"],"prefix":"10.1111","volume":"30","author":[{"given":"Nan\u2010Hyung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Dermatology Dongguk University Ilsan Hospital Goyang\u2010si Gyeonggi\u2010do South 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