{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:20:05Z","timestamp":1790688005355,"version":"4.1.0"},"reference-count":68,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T00:00:00Z","timestamp":1507852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT104076MA"],"award-info":[{"award-number":["WT104076MA"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Systematic work in the mouse and chicken has mapped out two neural crest\u2010derived pathways of melanocyte precursor migration. With these in mind, this study reappraises the patterns of congenital pigmentary disorders in humans and identifies three recurrent patterns consistent across genetically different diseases. Only two of these are seen in diseases known to be melanocyte cell\u2010autonomous. The segmental pattern correlates well with the classical dorsolateral population from animal studies, demonstrating respect of the midline, cranio\u2010caudal axial mixing, unilateral migration and involvement of key epidermally derived structures. Importantly however, the melanocyte precursors responsible for the non\u2010segmental pattern, which demonstrates circular, bilateral migration centred on the midline, and not involving key epidermally derived structures, have not been identified previously. We propose that this population originates around the time of gastrulation, most likely within the mesoderm, and ultimately resides within the dermis. Whether it contributes to mature melanocytes in non\u2010disease states is not known; however, parallels with the patterns of acquired vitiligo would suggest that it does. The third pattern, hypo\u2010 or hyperpigmented fine and whorled Blaschko's lines, is proposed to be non\u2010cell\u2010autonomous.<\/jats:p>","DOI":"10.1111\/pcmr.12645","type":"journal-article","created":{"date-parts":[[2017,9,23]],"date-time":"2017-09-23T07:00:43Z","timestamp":1506150043000},"page":"95-109","source":"Crossref","is-referenced-by-count":47,"title":["The patterns of birthmarks suggest a novel population of melanocyte precursors arising around the time of gastrulation"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6256-327X","authenticated-orcid":false,"given":"Veronica A.","family":"Kinsler","sequence":"first","affiliation":[{"name":"Genetics and Genomic Medicine UCL Institute of Child Health  London UK"},{"name":"Paediatric Dermatology Great Ormond Street Hospital for Children NHS Foundation Trust  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2010-6107","authenticated-orcid":false,"given":"Lionel","family":"Larue","sequence":"additional","affiliation":[{"name":"Institut Curie INSERM U1021 Normal and Pathological Development of Melanocytes PSL Research University  Orsay France"},{"name":"Univ Paris\u2010Sud Univ Paris\u2010Saclay CNRS UMR 3347  Orsay France"},{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer  Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.07.049"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1997)9:5<452::AID-HUMU12>3.0.CO;2-1"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0501263102"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1965.tb00335.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12610"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3424"},{"key":"e_1_2_6_8_1","unstructured":"Blaschko A.(1901).Die Nervenverteilung in der Haut in ihrer Beziehung zu den Erkrankungen der Haut. 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