{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T14:35:27Z","timestamp":1780324527963,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T00:00:00Z","timestamp":1511308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2014\/10042\u20105"],"award-info":[{"award-number":["2014\/10042\u20105"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study aimed to evaluate whether PD1.1 (c.\u2010606G&gt;A), PD1 (c.627\u00a0+\u00a0252C&gt;T), PD1.5 (c.804C&gt;T), and PD1.9 (c.644C&gt;T) single nucleotide polymorphisms of <jats:italic>PDCD1<\/jats:italic> gene influence the risk, clinicopathological aspects, and survival of cutaneous melanoma (CM). Individuals with phototype I or II and PD1 CC genotype were under 5.89\u2010fold increased risk of developing CM. PD1.5 TT genotype increased <jats:italic>PDCD1<\/jats:italic> expression (2.49 versus 1.28 arbitrary units, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.03) and PD1.5 CT or TT genotype and allele T increased PD1 expression in TCD4<jats:sup>+<\/jats:sup> lymphocytes (16.6 versus 12.5%, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.01; 17.0 versus 13.1%, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.006). At 60\u00a0months of follow\u2010up, short recurrence\u2010free survival was seen in patients with PD1.1 AA genotype (33.3 versus 71.8%, <jats:italic>p\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>.03). Patients with PD1.1 AA and PD1.5 CC genotype had 4.21 and 2.62 more chances of presenting relapse and evolving death by disease in Cox analyses, respectively. Our data provide preliminary evidence that abnormalities in regulation of T lymphocyte alter CM risk, clinical aspects, and prognosis.<\/jats:p>","DOI":"10.1111\/pcmr.12665","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T07:36:38Z","timestamp":1509521798000},"page":"308-317","source":"Crossref","is-referenced-by-count":17,"title":["<i>PDCD1<\/i> gene polymorphisms as regulators of T\u2010lymphocyte activity in cutaneous melanoma risk and prognosis"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4367-4414","authenticated-orcid":false,"given":"Gabriela V. 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