{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T22:16:54Z","timestamp":1790374614407,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This cross\u2010sectional multicenter study aimed to evaluate serum <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010, as an activity marker for vitiligo, and compare it with other putative serum and tissue markers. Serum <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010 was compared to interferon gamma (<jats:styled-content style=\"fixed-case\">IFN<\/jats:styled-content>\u2010\u03b3), interleukin 6 (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106), and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017 using <jats:styled-content style=\"fixed-case\">ELISA<\/jats:styled-content> in 55 non\u2010segmental vitiligo patients (30 active and 25 stable) and 30 healthy controls. Marginal skin biopsy was taken for immunohistochemical evaluation of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+T cells and <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010+ve cells. Serum levels of <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010, <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201017, and <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 were elevated in all vitiligo patients compared to controls (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). All investigated serum markers were higher in active versus stable vitiligo. Tissue expression of <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010+ve cells and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8+ve T cells was stronger in vitiligo patients compared to controls, and tissue <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010+ve cell expression was stronger in active versus stable cases. Positive correlations were noted between the different serum and tissue markers. <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>\u201010 was the most specific, whereas <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u20106 was the most sensitive serum marker to distinguish active from stable disease.<\/jats:p>","DOI":"10.1111\/pcmr.12667","type":"journal-article","created":{"date-parts":[[2017,11,2]],"date-time":"2017-11-02T04:45:28Z","timestamp":1509597928000},"page":"330-336","source":"Crossref","is-referenced-by-count":62,"title":["<scp>CXCL<\/scp>\u201010 and Interleukin\u20106 are reliable serum markers for vitiligo activity: A multicenter cross\u2010sectional study"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7791-9141","authenticated-orcid":false,"given":"Marwa","family":"Abdallah","sequence":"first","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Medhat","family":"El\u2010Mofty","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tag","family":"Anbar","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department Minya University  Al\u2010 Minya Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoda","family":"Rasheed","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Esmat","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Al\u2010Tawdy","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa M.","family":"Fawzy","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Abdel\u2010Halim","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehab","family":"Hegazy","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba","family":"Gawdat","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Bassiouny","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona A.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Sany","sequence":"additional","affiliation":[{"name":"Dermatology Department Cairo University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahy","family":"El\u2010Bassiouny","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Khalil","sequence":"additional","affiliation":[{"name":"Dermatology, Venereology and Andrology Department Ain Shams University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abeer","family":"Abdel\u2010Aziz","sequence":"additional","affiliation":[{"name":"Haud El Marsoud Dermatology Hospital MOH  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab M.","family":"El Maadawi","sequence":"additional","affiliation":[{"name":"Histology &amp; 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