{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:07:43Z","timestamp":1782252463897,"version":"3.54.5"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T00:00:00Z","timestamp":1515542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001171","name":"Cancer Institute NSW","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Historically, the prognosis of patients with melanoma brain metastases is poor, with median overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) of 4\u20106\u00a0months. Little is known of<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>in the era of modern systemic therapies and local therapy with stereotactic radiosurgery (<jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content>) or surgery. Patients diagnosed with melanoma brain metastases at Melanoma Institute Australia from January 2011 to December 2014 were included.<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>and prognostic factors were analysed using Cox regression and Kaplan\u2010Meier survival analyses.355 patients were included. The median<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>was 7.1 months (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 6.0\u20108.1). Median<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>differed by treatment modality: systemic therapy and<jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content>and\/or surgery 14.9\u00a0months (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>10.7\u201019.0),<jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content>and\/or surgery with or without whole brain radiotherapy (<jats:styled-content style=\"fixed-case\">WBRT<\/jats:styled-content>) 6.4\u00a0months (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>5.4\u20107.5), systemic therapy 5.4\u00a0months (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>3.1\u20107.7), systemic therapy and<jats:styled-content style=\"fixed-case\">WBRT<\/jats:styled-content>5.2\u00a0months (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>4.1\u20106.4),<jats:styled-content style=\"fixed-case\">WBRT<\/jats:styled-content>4.4\u00a0months (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>2.4\u20106.3), and best supportive care 1.8\u00a0months (95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>1.2\u20102.3).<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>for patients with melanoma brain metastases appears improved in the modern era, particularly for patients who are candidates for systemic therapy with<jats:styled-content style=\"fixed-case\">SRS<\/jats:styled-content>and\/or surgery.<\/jats:p>","DOI":"10.1111\/pcmr.12682","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T08:06:48Z","timestamp":1514275608000},"page":"509-515","source":"Crossref","is-referenced-by-count":41,"title":["Survival and prognostic factors for patients with melanoma brain metastases in the era of modern systemic therapy"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3156-3108","authenticated-orcid":false,"given":"Martin","family":"Tio","sequence":"first","affiliation":[{"name":"Department of Medical Oncology Royal North Shore Hospital St Leonards NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University Cancer Hospital and Institute Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo S.","family":"Carlino","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia North Sydney NSW Australia"},{"name":"Crown Princess Mary Cancer Centre Westmead Sydney NSW Australia"},{"name":"Sydney Medical School The University of Sydney Camperdown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brindha","family":"Shivalingam","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia North Sydney NSW Australia"},{"name":"Sydney Medical School The University of Sydney Camperdown NSW Australia"},{"name":"Royal Prince Alfred Hospital Camperdown NSW Australia"},{"name":"Mater Hospital North Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald B.","family":"Fogarty","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia North Sydney NSW Australia"},{"name":"Sydney Medical School The University of Sydney Camperdown NSW Australia"},{"name":"Mater Hospital North Sydney NSW Australia"},{"name":"Genesis Cancer Care Mater Radiation Oncology North Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander D.","family":"Guminski","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Royal North Shore Hospital St Leonards NSW Australia"},{"name":"Melanoma Institute Australia North Sydney NSW Australia"},{"name":"Sydney Medical School The University of Sydney Camperdown NSW Australia"},{"name":"Mater Hospital North Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serigne","family":"Lo","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia North Sydney NSW Australia"},{"name":"Sydney Medical School The University of Sydney Camperdown NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela M.","family":"Hong","sequence":"additional","affiliation":[{"name":"Melanoma Institute Australia North Sydney NSW Australia"},{"name":"Sydney Medical School The University of Sydney Camperdown NSW Australia"},{"name":"Mater Hospital North Sydney NSW Australia"},{"name":"Genesis Cancer Care Mater Radiation Oncology North Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M.","family":"Menzies","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Royal North Shore Hospital St Leonards NSW Australia"},{"name":"Melanoma Institute Australia North Sydney NSW Australia"},{"name":"Sydney Medical School The University of Sydney Camperdown NSW Australia"},{"name":"Mater Hospital North Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina V.","family":"Long","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Royal North Shore Hospital St Leonards NSW Australia"},{"name":"Melanoma Institute Australia North Sydney NSW Australia"},{"name":"Sydney Medical School The University of Sydney Camperdown NSW Australia"},{"name":"Mater Hospital North Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdw417"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.12.149"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-013-0466-2"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30441-2"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.287"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2015.1046028"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.01.007"},{"issue":"2","key":"e_1_2_8_9_1","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox D. R.","year":"1972","journal-title":"Journal of the Royal Statistical Society, Series B"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.25634"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30429-1"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2013.11.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.08.140"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30053-5"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.12.FOCUS14698"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.01.004"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.9508"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70431-X"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(17)30414-X"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70090-6"},{"issue":"3","key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1093\/annonc\/mdw641","article-title":"Vemurafenib in metastatic melanoma patients with brain metastases: An open\u2010label, single\u2010arm, phase 2, multicentre study","volume":"28","author":"McArthur G. A.","year":"2017","journal-title":"Annals of Oncology"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19961001)78:7<1470::AID-CNCR14>3.0.CO;2-X"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-007-9510-4"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-011-0203-y"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpor.2015.12.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199002223220802"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-2007-058"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2014.10.024"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-015-0095-8"},{"issue":"3","key":"e_1_2_8_31_1","first-page":"CD009454","article-title":"Surgery or radiosurgery plus whole brain radiotherapy versus surgery or radiosurgery alone for brain metastases","volume":"2014","author":"Soon Y. Y.","year":"2014","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2016.03.003"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605622"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.9507"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.315"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000029"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410330605"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12682","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12682","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T03:05:18Z","timestamp":1719716718000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,10]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/pcmr.12682"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12682","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,10]]}}}