{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T11:41:55Z","timestamp":1790509315595,"version":"4.1.0"},"reference-count":90,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T00:00:00Z","timestamp":1517184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24\u2010OD\u2010011120"],"award-info":[{"award-number":["R24\u2010OD\u2010011120"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24\u2010OD\u2010011199"],"award-info":[{"award-number":["R24\u2010OD\u2010011199"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R24\u2010OD\u2010018555"],"award-info":[{"award-number":["R24\u2010OD\u2010018555"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Comparative analysis of human and animal model melanomas can uncover conserved pathways and genetic changes that are relevant for the biology of cancer cells. Spontaneous melanoma in <jats:italic>Xiphophorus<\/jats:italic> interspecies backcross hybrid progeny may be informative in identifying genes and functional pathways that are similarly related to melanoma development in all vertebrates, including humans. To assess functional pathways involved in the <jats:italic>Xiphophorus<\/jats:italic> melanoma, we performed gene expression profiling of the melanomas produced in interspecies <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content><jats:sub>1<\/jats:sub> and successive backcross generations (i.e., <jats:styled-content style=\"fixed-case\">BC<\/jats:styled-content><jats:sub>5<\/jats:sub>) of the cross: <jats:italic>X.\u00a0hellerii<\/jats:italic>\u00a0\u00d7\u00a0[<jats:italic>X.\u00a0maculatus<\/jats:italic> Jp 163 A\u00a0\u00d7\u00a0<jats:italic>X.\u00a0hellerii<\/jats:italic>]. Using <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>\u2010Seq, we identified genes that are transcriptionally co\u2010expressed with the driver oncogene, <jats:italic>xmrk<\/jats:italic>. We determined functional pathways in the fish melanoma that are also present in human melanoma cohorts that may be related to dedifferentiation based on the expression levels of pigmentation genes. Shared pathways between human and <jats:italic>Xiphophorus<\/jats:italic> melanomas are related to inflammation, cell migration, cell proliferation, pigmentation, cancer development, and metastasis. Our results suggest <jats:italic>xmrk<\/jats:italic> co\u2010expressed genes are associated with dedifferentiation and highlight these signaling pathways as playing important roles in melanomagenesis.<\/jats:p>","DOI":"10.1111\/pcmr.12686","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T09:01:13Z","timestamp":1515574873000},"page":"496-508","source":"Crossref","is-referenced-by-count":15,"title":["Comparison of <i>Xiphophorus<\/i> and human melanoma transcriptomes reveals conserved pathway interactions"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2420-4804","authenticated-orcid":false,"given":"Yuan","family":"Lu","sequence":"first","affiliation":[{"name":"The Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry Texas State University  San Marcos TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikki","family":"Boswell","sequence":"additional","affiliation":[{"name":"The Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry Texas State University  San Marcos TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Boswell","sequence":"additional","affiliation":[{"name":"The Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry Texas State University  San Marcos TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Kneitz","sequence":"additional","affiliation":[{"name":"Physiological Chemistry, Biozentrum University of W\u00fcrzburg  W\u00fcrzburg Germany"},{"name":"Comprehensive Cancer Center Mainfranken University Clinic W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hausmann","sequence":"additional","affiliation":[{"name":"Physiological Chemistry, Biozentrum University of W\u00fcrzburg  W\u00fcrzburg Germany"},{"name":"Comprehensive Cancer Center Mainfranken University Clinic W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Klotz","sequence":"additional","affiliation":[{"name":"Physiological Chemistry, Biozentrum University of W\u00fcrzburg  W\u00fcrzburg Germany"},{"name":"Comprehensive Cancer Center Mainfranken University Clinic W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Regneri","sequence":"additional","affiliation":[{"name":"Physiological Chemistry, Biozentrum University of W\u00fcrzburg  W\u00fcrzburg Germany"},{"name":"Comprehensive Cancer Center Mainfranken University Clinic W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markita","family":"Savage","sequence":"additional","affiliation":[{"name":"The Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry Texas State University  San Marcos TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Amores","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience University of Oregon  Eugene OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Postlethwait","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience University of Oregon  Eugene OR USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley","family":"Warren","sequence":"additional","affiliation":[{"name":"The Genome Institute Washington University School of Medicine  St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manfred","family":"Schartl","sequence":"additional","affiliation":[{"name":"Physiological Chemistry, Biozentrum University of W\u00fcrzburg  W\u00fcrzburg Germany"},{"name":"Comprehensive Cancer Center Mainfranken University Clinic W\u00fcrzburg  W\u00fcrzburg Germany"},{"name":"Texas A&amp;M Institute for Advanced Studies and Department of Biology Texas A&amp;M University  College Station TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Walter","sequence":"additional","affiliation":[{"name":"The Xiphophorus Genetic Stock Center, Department of Chemistry and Biochemistry Texas State University  San Marcos TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,29]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"73","article-title":"Transcriptional activation of the melanoma inducing Xmrk oncogene in Xiphophorus","volume":"6","author":"Adam D.","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-016-0485-x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25735"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11071"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.03.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.06.006"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09161"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01271.x"},{"issue":"27","key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"41142","DOI":"10.18632\/oncotarget.9220","article-title":"Reprogramming human A375 amelanotic melanoma cells by catalase overexpression: Reversion or promotion of malignancy by inducing melanogenesis or metastasis","volume":"7","author":"Bracalente C.","year":"2016","journal-title":"Oncotarget"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03269"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.406406"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103782"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.598"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.425"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2009.00653.x"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00766"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(03)00817-5"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.109.6.3115"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60398-5"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btl567"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1210093"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1002011"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41004"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2011.05.012"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03664"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(02)00004-6"},{"issue":"16","key":"e_1_2_9_28_1","first-page":"4820","article-title":"Autocrine stimulation by osteopontin contributes to antiapoptotic signalling of melanocytes in dermal collagen","volume":"62","author":"Geissinger E.","year":"2002","journal-title":"Cancer Research"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1053"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-0902"},{"issue":"3","key":"e_1_2_9_31_1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1093\/genetics\/12.3.253","article-title":"The genetics of a viviparous top\u2010minnow Platypoecilus; the inheritance of two kinds of melanophores","volume":"12","author":"Gordon M.","year":"1927","journal-title":"Genetics"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60868-X"},{"key":"e_1_2_9_33_1","first-page":"1561","article-title":"\u00dcber Melanombildungen bei Bastarden von Xiphophorus Helleri und Platypoecilus maculatus var. rubra","volume":"7","author":"H\u00e4ussler G.","year":"1928","journal-title":"Journal of Molecular Medicine"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2010.00757.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.26724"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI39104"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199807)22:3<210::AID-GCC6>3.0.CO;2-Z"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1202884"},{"key":"e_1_2_9_39_1","first-page":"253","article-title":"\u00dcber Bastarde der Teleostier Platypoecilus und Xiphophorus","volume":"44","author":"Kosswig C.","year":"1928","journal-title":"Zeitschrift Fur Induktive Abstammungs\u2010 Und Vererbungslehre"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11538"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1923"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.016634"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2012.10.009"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200410115"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.4327"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70431-X"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/mc.22651"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2015.07.011"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.5301\/jbm.5000209"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100913-013116"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2004.06.002"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207675"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205148"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-381320-6.00014-X"},{"key":"e_1_2_9_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2015.355"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-0781"},{"key":"e_1_2_9_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.01.010"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9755"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.04.034"},{"key":"e_1_2_9_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btp616"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2011.60"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.05.009"},{"key":"e_1_2_9_63_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037880"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143057"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2604"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.213"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.03.023"},{"key":"e_1_2_9_68_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M400441200"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1925fje"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-015-2361-z"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbd.2012.10.006"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20138"},{"key":"e_1_2_9_73_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.105445"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.10978"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01726-9"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-200206000-00001"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1230717"},{"key":"e_1_2_9_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpc.2014.01.006"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar.42.4.299"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.418"},{"key":"e_1_2_9_81_1","first-page":"47","volume-title":"Cancer: A comprehensive treatise","author":"We H.","year":"1982"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(19980504)76:3<437::AID-IJC24>3.0.CO;2-6"},{"key":"e_1_2_9_83_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1999.4580"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.1999.00180.x"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1432-1327.2000.01378.x"},{"key":"e_1_2_9_86_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110684200"},{"issue":"3","key":"e_1_2_9_87_1","first-page":"711","article-title":"Induction of tumorigenicity and lack of in vitro growth requirement for 12\u2010O\u2010tetradecanoylphorbol\u201013\u2010acetate by transfection of murine melanocytes with v\u2010Ha\u2010ras","volume":"49","author":"Wilson R. E.","year":"1989","journal-title":"Cancer Research"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/341415a0"},{"key":"e_1_2_9_89_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1604958"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.5582\/bst.2015.01106"},{"key":"e_1_2_9_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2015.12.001"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12686","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12686","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T11:03:00Z","timestamp":1694343780000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12686"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,29]]},"references-count":90,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1111\/pcmr.12686"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12686","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,29]]}}}