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Once disseminated, it is usually highly resistant to chemotherapy and is associated with poor prognosis. We have recently reported that T\u2010type calcium channels (<jats:styled-content style=\"fixed-case\">TTCC<\/jats:styled-content>s) are overexpressed in melanoma cells and play an important role in melanoma progression. Importantly, <jats:styled-content style=\"fixed-case\">TTCC<\/jats:styled-content> pharmacological blockers reduce proliferation and deregulate autophagy leading to apoptosis. Here, we analyze the role of autophagy during migration\/invasion of melanoma cells. <jats:styled-content style=\"fixed-case\">TTCC<\/jats:styled-content> Cav3.1 and <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>3\u2010<jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> proteins are highly expressed in <jats:styled-content style=\"fixed-case\">BRAFV<\/jats:styled-content>600E compared with <jats:styled-content style=\"fixed-case\">NRAS<\/jats:styled-content> mutant melanomas, both in cell lines and biopsies. Chloroquine, pharmacological blockade, or gene silencing of <jats:styled-content style=\"fixed-case\">TTCC<\/jats:styled-content>s inhibit the autophagic flux and impair the migration and invasion capabilities, specifically in <jats:styled-content style=\"fixed-case\">BRAFV<\/jats:styled-content>600E melanoma cells. Snail1 plays an important role in motility and invasion of melanoma cells. We show that Snail1 is strongly expressed in <jats:styled-content style=\"fixed-case\">BRAFV<\/jats:styled-content>600E melanoma cells and patient biopsies, and its expression decreases when autophagy is blocked. These results demonstrate a role of Snail1 during <jats:styled-content style=\"fixed-case\">BRAFV<\/jats:styled-content>600E melanoma progression and strongly suggest that targeting macroautophagy and, particularly <jats:styled-content style=\"fixed-case\">TTCC<\/jats:styled-content>s, might be a good therapeutic strategy to inhibit metastasis of the most common melanoma type (<jats:styled-content style=\"fixed-case\">BRAFV<\/jats:styled-content>600E).<\/jats:p>","DOI":"10.1111\/pcmr.12690","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T23:58:38Z","timestamp":1517443118000},"page":"484-495","source":"Crossref","is-referenced-by-count":21,"title":["T\u2010type calcium channels drive migration\/invasion in <scp>BRAFV<\/scp>600E melanoma cells through Snail1"],"prefix":"10.1111","volume":"31","author":[{"given":"Oscar","family":"Maiques","sequence":"first","affiliation":[{"name":"University of Lleida IRBLleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Barcel\u00f3","sequence":"additional","affiliation":[{"name":"University of Lleida IRBLleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana\u00efs","family":"Panosa","sequence":"additional","affiliation":[{"name":"University of Lleida IRBLleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Pijuan","sequence":"additional","affiliation":[{"name":"University of Lleida IRBLleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose L.","family":"Orgaz","sequence":"additional","affiliation":[{"name":"Tumour Plasticity Laboratory Randall Division of Cell and Molecular Biophysics New Hunt's House King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Rodriguez\u2010Hernandez","sequence":"additional","affiliation":[{"name":"Tumour Plasticity Laboratory Randall Division of Cell and Molecular Biophysics New Hunt's House King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Matas\u2010Nadal","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Universitari Arnau de Vilanova University of Lleida IRBLleida  Lleida Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Tell","sequence":"additional","affiliation":[{"name":"Melanoma Unit Department of Dermatology Hospital Cl\u00ednic de Barcelona Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) University of Barcelona  Barcelona Spain"},{"name":"Centre of Biomedical Research on Rare Diseases (CIBERER) Instituto de Salud Carlos III (ISCIII)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Vilella","sequence":"additional","affiliation":[{"name":"Department of Immunology Hospital Cl\u00ednic  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angels","family":"Fabra","sequence":"additional","affiliation":[{"name":"Molecular Oncology Bellvitge Biomedical Research Institute (IDIBELL) L'Hospitalet de Llobregat  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Puig","sequence":"additional","affiliation":[{"name":"Melanoma Unit Department of Dermatology Hospital Cl\u00ednic de Barcelona Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) University of Barcelona  Barcelona Spain"},{"name":"Centre of Biomedical Research on Rare Diseases (CIBERER) Instituto de Salud Carlos III (ISCIII)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Sanz\u2010Moreno","sequence":"additional","affiliation":[{"name":"Tumour Plasticity Laboratory Randall Division of Cell and Molecular Biophysics New Hunt's House King's College 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