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While <jats:styled-content style=\"fixed-case\">BRN<\/jats:styled-content>2 is a central regulator in numerous developmental programs, it has also emerged as a major player in the biology of tumourigenesis. In melanoma, <jats:styled-content style=\"fixed-case\">BRN<\/jats:styled-content>2 has been implicated as one of the master regulators of the acquisition of invasive behaviour within the phenotype switching model of progression. As a mediator of melanoma cell phenotype switching, it coordinates the transition to a dedifferentiated, slow cycling and highly motile cell type. Its inverse expression relationship with <jats:styled-content style=\"fixed-case\">MITF<\/jats:styled-content> is believed to mediate tumour progression and metastasis within this model. Recent evidence has now outlined a potential epigenetic switching mechanism in melanoma cells driven by <jats:styled-content style=\"fixed-case\">BRN<\/jats:styled-content>2 expression that induces melanoma cell invasion. We summarize the role of <jats:styled-content style=\"fixed-case\">BRN<\/jats:styled-content>2 in tumour cell dissemination and metastasis in melanoma, while also examining it as a potential metastatic regulator in other tumour models.<\/jats:p>","DOI":"10.1111\/pcmr.12710","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T12:25:35Z","timestamp":1526905535000},"page":"9-24","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["<scp>BRN<\/scp>2, a <scp>POU<\/scp>erful driver of melanoma phenotype switching and metastasis"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6163-5753","authenticated-orcid":false,"given":"Mitchell E.","family":"Fane","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences Institute of Health and Biomedical Innovation at the Translational Research Institute Queensland University of Technology  Brisbane 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