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To better understand the development of melanocytes in the mouse tail, we cloned two dominant <jats:styled-content style=\"fixed-case\">ENU<\/jats:styled-content>\u2010generated mutations of the <jats:italic>Adamts9<\/jats:italic> gene, <jats:italic>Und3<\/jats:italic> and <jats:italic>Und4<\/jats:italic>, which cause an unpigmented ring of epidermis in the middle of the tail, but do not alter pigmentation in the rest of the mouse. <jats:italic>Adamts9<\/jats:italic> encodes a widely expressed zinc metalloprotease with thrombospondin type 1 repeats with few known substrates. Melanocytes are lost in the <jats:italic>Adamts9<\/jats:italic> mutant tail epidermis at a relatively late stage of development, around E18.5. Studies of our <jats:italic>Adamts9<\/jats:italic> conditional allele suggest that there is a melanocyte cell\u2010autonomous requirement for <jats:italic>Adamts9<\/jats:italic>. In addition, we used a proteomics approach, <jats:styled-content style=\"fixed-case\">TAILS<\/jats:styled-content> N\u2010terminomics, to identify new Adamts9 candidate substrates in the extracellular matrix of the skin. The tail phenotype of <jats:italic>Adamts9<\/jats:italic> mutants is strikingly similar to the unpigmented trunk belt in <jats:italic>Adamts20<\/jats:italic> mutants, which suggests a particular requirement for Adamts family activity at certain positions along the anterior\u2013posterior axis.<\/jats:p>","DOI":"10.1111\/pcmr.12711","type":"journal-article","created":{"date-parts":[[2018,5,21]],"date-time":"2018-05-21T12:21:26Z","timestamp":1526905286000},"page":"693-707","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Melanocyte development in the mouse tail epidermis requires the Adamts9 metalloproteinase"],"prefix":"10.1111","volume":"31","author":[{"given":"Grace","family":"Tharmarajah","sequence":"first","affiliation":[{"name":"Department of Medical Genetics Life Sciences Institute University of British Columbia  Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5863-4514","authenticated-orcid":false,"given":"Ulrich","family":"Eckhard","sequence":"additional","affiliation":[{"name":"Department of Oral Biological and Medical Sciences Faculty of Dentistry Centre for Blood Research Life Sciences Institute University of British Columbia  Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fagun","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Life Sciences Institute University of British Columbia  Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giada","family":"Marino","sequence":"additional","affiliation":[{"name":"Department of Oral Biological and Medical Sciences Faculty of Dentistry Centre for Blood Research Life Sciences Institute University of British Columbia  Vancouver BC 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