{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:57:36Z","timestamp":1789617456406,"version":"build-2803163510"},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this perspective, we identify emerging frontiers in clinical and basic research of melanocyte biology and its associated biomedical disciplines. We describe challenges and opportunities in clinical and basic research of normal and diseased melanocytes that impact current approaches to research in melanoma and the dermatological sciences. We focus on four themes: (1) clinical melanoma research, (2) basic melanoma research, (3) clinical dermatology, and (4) basic pigment cell research, with the goal of outlining current highlights, challenges, and frontiers associated with pigmentation and melanocyte biology.<\/jats:p><jats:p>Significantly, this document encapsulates important advances in melanocyte and melanoma research including emerging frontiers in melanoma immunotherapy, medical and surgical oncology, dermatology, vitiligo, albinism, genomics and systems biology, epidemiology, pigment biophysics and chemistry, and evolution.<\/jats:p>","DOI":"10.1111\/pcmr.12728","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T14:34:45Z","timestamp":1538750085000},"page":"728-735","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Frontiers in pigment cell and melanoma research"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9889-5727","authenticated-orcid":false,"given":"Fabian V.","family":"Filipp","sequence":"first","affiliation":[{"name":"Systems Biology and Cancer Metabolism Program for Quantitative Systems Biology University of California Merced  Merced California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanca","family":"Birlea","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Colorado Denver  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus W.","family":"Bosenberg","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Dermatopathology Yale School of Medicine  New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Brash","sequence":"additional","affiliation":[{"name":"Department of Therapeutic Radiology Yale School of Medicine  New Haven Connecticut"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela B.","family":"Cassidy","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health and Science University  Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzie","family":"Chen","sequence":"additional","affiliation":[{"name":"Susan Lehman Cullman Laboratory for Cancer Research Department of Chemical Biology Ernest Mario School of Pharmacy Rutgers University  Piscataway New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"D'Orazio","sequence":"additional","affiliation":[{"name":"Markey Cancer Center University of Kentucky College of Medicine  Lexington Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Colorado Denver  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boon\u2010Kee","family":"Goh","sequence":"additional","affiliation":[{"name":"Mount Elizabeth Medical Centre Skin Physicians Private Limited  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meenhard","family":"Herlyn","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Oncogenesis Wistar Institute  Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arup K.","family":"Indra","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health and Science University  Portland Oregon"},{"name":"Department of Pharmaceutical Sciences College of Pharmacy Oregon State University  Corvallis Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Larue","sequence":"additional","affiliation":[{"name":"Equipe Labellis\u00e9e Ligue Contre le Cancer, Normal and Pathological Development of Melanocytes UMR 3347 CNRS Institut Curie  Orsay France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sancy A.","family":"Leachman","sequence":"additional","affiliation":[{"name":"Department of Dermatology Oregon Health and Science University  Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Le Poole","sequence":"additional","affiliation":[{"name":"Lurie Comprehensive Cancer Center Northwestern University at Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Liu\u2010Smith","sequence":"additional","affiliation":[{"name":"Chao Family Comprehensive Cancer Center University of California Irvine  Orange California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashiela","family":"Manga","sequence":"additional","affiliation":[{"name":"Ronald O Perlman Department of Dermatology New York University Langone Medical Center  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluis","family":"Montoliu","sequence":"additional","affiliation":[{"name":"CNB\u2010CSIC, CIBERER\u2010ISCIII, Campus de Cantoblanco Centro Nacional de Biotecnolog\u00eda  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Norris","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Colorado Denver  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiqun","family":"Shellman","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Colorado Denver  Aurora Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiran S. 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