{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:22:50Z","timestamp":1760242970158,"version":"3.37.3"},"reference-count":31,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,9,24]],"date-time":"2018-09-24T00:00:00Z","timestamp":1537747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["R01\u2014CA142873"],"award-info":[{"award-number":["R01\u2014CA142873"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The deubiquitinating enzyme <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1 is mutated in a hereditary cancer syndrome with a high risk of mesothelioma and melanocytic tumors. Here, we show that <jats:italic>Bap1<\/jats:italic> deletion in melanocytes cooperates with the constitutively active, oncogenic form of BRAF (BRAF<jats:sup>V600E<\/jats:sup>) and <jats:styled-content style=\"fixed-case\">UV<\/jats:styled-content> to cause melanoma in mice, albeit at very low frequency. In addition, <jats:italic>Bap1<\/jats:italic>\u2010null melanoma cells derived from mouse tumors are more aggressive and colonize and grow at distant sites more than their wild\u2010type counterparts. Molecularly, <jats:italic>Bap1<\/jats:italic>\u2010null melanoma cell lines have increased <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> damage measured by \u03b3H2aX and hyperubiquitination of histone H2a. Therapeutically, these <jats:italic>Bap1<\/jats:italic>\u2010null tumors are completely responsive to <jats:styled-content style=\"fixed-case\">BRAF<\/jats:styled-content>\u2010 and <jats:styled-content style=\"fixed-case\">MEK<\/jats:styled-content>\u2010targeted therapies. Therefore, <jats:styled-content style=\"fixed-case\">BAP<\/jats:styled-content>1 functions as a tumor suppressor and limits tumor progression in melanoma.<\/jats:p>","DOI":"10.1111\/pcmr.12735","type":"journal-article","created":{"date-parts":[[2018,8,30]],"date-time":"2018-08-30T06:42:21Z","timestamp":1535611341000},"page":"269-279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The tumor suppressor <scp>BAP<\/scp>1 cooperates with <scp>BRAFV<\/scp>600E to promote tumor formation in cutaneous melanoma"],"prefix":"10.1111","volume":"32","author":[{"given":"Joshua D.","family":"Webster","sequence":"first","affiliation":[{"name":"Department of Pathology Genentech, Inc.  South San Francisco California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trang H.","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Discovery Oncology Genentech, Inc.  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