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Because\n                    <jats:italic>TYRP1<\/jats:italic>\n                    is sex\u2010linked in chickens, and\n                    <jats:italic>TYRP1<\/jats:italic>\n                    mutations determine brown coat color in mammals,\n                    <jats:italic>TYRP1<\/jats:italic>\n                    appeared as the obvious candidate gene for the\n                    <jats:italic>choc<\/jats:italic>\n                    mutation. By combining gene mapping with gene capture, a complete association was identified between the chocolate phenotype and a missense mutation leading to a His214Asn change in the ZnA zinc\u2010binding domain of the protein. A diagnostic test confirmed complete association by screening 428 non\u2010chocolate chickens of various origins. This is the first\n                    <jats:italic>TYRP1<\/jats:italic>\n                    mutation described in the chicken. Electron microscopy analysis showed that melanosomes were more numerous in feather follicles of chocolate chickens but exhibited an abnormal structure characterized by a granular content and an irregular shape. A similar altered morphology was observed on melanosomes of another\n                    <jats:italic>TYRP1<\/jats:italic>\n                    mutant in birds, the\n                    <jats:italic>roux<\/jats:italic>\n                    mutation of the quail.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.12753","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T09:32:33Z","timestamp":1542706353000},"page":"381-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["A missense mutation in\n                    <i>TYRP1<\/i>\n                    causes the chocolate plumage color in chicken and alters melanosome structure"],"prefix":"10.1111","volume":"32","author":[{"given":"Jingyi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Animal and Poultry Sciences Virginia Tech Blacksburg Virginia"},{"name":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences Texas A&amp;M University College Station Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bertrand","family":"Bed\u2019hom","sequence":"additional","affiliation":[{"name":"GABI, AgroParisTech, INRA Universit\u00e9 Paris\u2010Saclay Jouy\u2010en\u2010Josas France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Marthey","sequence":"additional","affiliation":[{"name":"GABI, AgroParisTech, INRA Universit\u00e9 Paris\u2010Saclay Jouy\u2010en\u2010Josas France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Valade","sequence":"additional","affiliation":[{"name":"GABI, AgroParisTech, INRA Universit\u00e9 Paris\u2010Saclay Jouy\u2010en\u2010Josas France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Dureux","sequence":"additional","affiliation":[{"name":"GABI, AgroParisTech, INRA Universit\u00e9 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