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The aim of this large collaborative multicenter study was to determine potential key biomarkers for metastatic risk and any druggable targets for high metastatic risk CoM. Using Affymetrix single nucleotide polymorphism genotyping arrays on 59 CoM, we detected frequent amplifications on chromosome (chr) 6p and deletions on 7q, and characterized mutation\u2010specific copy number alterations. Deletions on chr 10q11.21\u201026.2, a region harboring the tumor suppressor genes, <jats:italic>PDCD4<\/jats:italic>,<jats:italic> SUFU<\/jats:italic>,<jats:italic> NEURL1<\/jats:italic>,<jats:italic> PTEN<\/jats:italic>, <jats:italic>RASSF4<\/jats:italic>,<jats:italic> DMBT1<\/jats:italic>, and<jats:italic> C10orf90<\/jats:italic> and<jats:italic> C10orf99<\/jats:italic>, significantly correlated with metastasis (Fisher's exact, <jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.04), lymphatic invasion (Fisher's exact, <jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.02), increasing tumor thickness (Mann\u2013Whitney, <jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.02), and <jats:italic>BRAF<\/jats:italic> mutation (Fisher's exact, <jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.05). This enhanced insight into CoM biology is a step toward identifying patients at risk of metastasis and potential therapeutic targets for systemic disease.<\/jats:p>","DOI":"10.1111\/pcmr.12767","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T16:33:05Z","timestamp":1548347585000},"page":"564-575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Conjunctival melanoma copy number alterations and correlation with mutation status, tumor features, and clinical outcome"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7907-5344","authenticated-orcid":false,"given":"Nihal","family":"Kenawy","sequence":"first","affiliation":[{"name":"Liverpool Ocular Oncology Research Group Institute of Translational Medicine University of Liverpool Liverpool UK"},{"name":"Aintree University Hospital Liverpool 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