{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:11:49Z","timestamp":1787497909663,"version":"build-2736575974"},"reference-count":44,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T00:00:00Z","timestamp":1554422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1R15EB013439"],"award-info":[{"award-number":["1R15EB013439"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Although pigment synthesis is well understood, relevant mechanisms of psychologically debilitating dyspigmentation in nascent tissue after cutaneous injuries are still unknown. Here, differences in genomic transcription of hyper\u2010 and hypopigmented tissue relative to uninjured skin were investigated using a red Duroc swine scar model. Transcription profiles differed based on pigmentation phenotypes with a trend of more upregulation or downregulation in hyper\u2010 or hypopigmented scars, respectively. Ingenuity Pathway Analysis of significantly modulated genes in both pigmentation phenotypes showed pathways related to redox, metabolic, and inflammatory responses were more present in hypopigmented samples, while those related to stem cell development differentiation were found mainly in hyperpigmented samples. Cell\u2013cell and cell\u2013extracellular matrix interactions and inflammation responses were predicted (z\u2010score) active in hyperpigmented and inactive in hypopigmented. The proinflammatory high\u2010mobility group box 1 pathway showed the opposite trend. Analysis of differentially regulated mutually exclusive genes showed an extensive presence of metabolic, proinflammatory, and oxidative stress pathways in hypopigmented scars, while melanin synthesis, glycosaminoglycans biosynthesis, and cell differentiation pathways were predominant in hyperpigmented scar. Several potential therapeutic gene targets have been identified.<\/jats:p>","DOI":"10.1111\/pcmr.12780","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T12:54:39Z","timestamp":1552049679000},"page":"643-656","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dyspigmented hypertrophic scars: Beyond skin color"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9249-5164","authenticated-orcid":false,"given":"Abdulnaser","family":"Alkhalil","sequence":"first","affiliation":[{"name":"Firefighters' Burn and Surgical Research Laboratory MedStar Health Research Institute Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2292-4960","authenticated-orcid":false,"given":"Bonnie C.","family":"Carney","sequence":"additional","affiliation":[{"name":"Firefighters' Burn and Surgical Research Laboratory MedStar Health Research Institute Washington District of Columbia"},{"name":"Department of Biochemistry and Molecular and Cellular Biology Georgetown University School of Medicine Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taryn E.","family":"Travis","sequence":"additional","affiliation":[{"name":"Firefighters' Burn and Surgical Research Laboratory MedStar Health Research Institute Washington District of Columbia"},{"name":"Department of Surgery, The Burn Center MedStar Washington Hospital Center Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seid","family":"Muhie","sequence":"additional","affiliation":[{"name":"Integrative Systems Biology US Army Center for Environmental Health Research Fort Detrick Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy Ann","family":"Miller","sequence":"additional","affiliation":[{"name":"Integrative Systems Biology US Army Center for Environmental Health Research Fort Detrick Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica C.","family":"Ramella\u2010Roman","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Florida International University Miami Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pehman","family":"Ghassemi","sequence":"additional","affiliation":[{"name":"US Food and Drug Administration Center for Devices and Radiological Health Silver Spring Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasha","family":"Hammamieh","sequence":"additional","affiliation":[{"name":"Integrative Systems Biology US Army Center for Environmental Health Research Fort Detrick Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marti","family":"Jett","sequence":"additional","affiliation":[{"name":"Integrative Systems Biology US Army Center for Environmental Health Research Fort Detrick Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren T.","family":"Moffatt","sequence":"additional","affiliation":[{"name":"Firefighters' Burn and Surgical Research Laboratory MedStar Health Research Institute Washington District of Columbia"},{"name":"Department of Biochemistry and Molecular and Cellular Biology Georgetown University School of Medicine Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey W.","family":"Shupp","sequence":"additional","affiliation":[{"name":"Firefighters' Burn and Surgical Research Laboratory MedStar Health Research Institute Washington District of Columbia"},{"name":"Department of Biochemistry and Molecular and Cellular Biology Georgetown University School of Medicine Washington District of Columbia"},{"name":"Department of Surgery, The Burn Center MedStar Washington Hospital Center Washington District of Columbia"},{"name":"Department of Surgery Georgetown University School of Medicine Washington District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.13.s8.28.x"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200005000-00009"},{"key":"e_1_2_9_4_1","first-page":"e29","article-title":"A Translational animal model for scar compression therapy using an automated pressure delivery system","volume":"15","author":"Alkhalil A.","year":"2015","journal-title":"Eplasty"},{"issue":"4","key":"e_1_2_9_5_1","first-page":"616","article-title":"Activation and selective inhibition of a cyclic AMP\u2010specific phosphodiesterase, PDE\u20104D3","volume":"48","author":"Alvarez R.","year":"1995","journal-title":"Molecular Pharmacology"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(03)00067-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.15.8529834"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000413"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6649rev"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.12.045"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-0362(02)00218-0"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2005.02.001"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.01.026"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1967.01610030083015"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.5.003337"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700151"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00739"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/skinbio.2011.4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0305-4179(96)88885-1"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12242.x"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05660"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.2005.tb01532.x"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/371799a0"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-1097.1999.tb03347.x"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00762-6"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-285-4_26"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780273"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00358.x"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2010.08.014"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/750482"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2004.09.013"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2005.11.002"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2016.03.012"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2009.00912.x"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.09.014"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2009.00610.x"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00044.2003"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.1647545"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-475x.2001.00066.x"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2015.10.040"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000154"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000154"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/BCR.0000000000000097"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a017046"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-4179(03)00205-5"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fpcmr.12780","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12780","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pcmr.12780","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12780","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T10:50:50Z","timestamp":1694256650000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12780"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,5]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1111\/pcmr.12780"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12780","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,5]]},"assertion":[{"value":"2018-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}