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Despite being a common cause for visual impairment worldwide, there is a paucity of treatments and patients typically suffer lifelong visual disability. Residual plasticity of the developing retina in young children with albinism has been demonstrated, suggesting a post\u2010natal window for therapeutic rescue. L\u20103, 4 dihydroxyphenylalanine (L\u2010DOPA), a key signalling molecule which is essential for normal retinal development, is known to be deficient in albinism. In this study, we demonstrate for the first time that post\u2010natal L\u2010DOPA supplementation can rescue retinal development, morphology and visual function in a murine model of human albinism, but only if administered from birth or 15\u00a0days post\u2010natal age.<\/jats:p>","DOI":"10.1111\/pcmr.12782","type":"journal-article","created":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T15:48:51Z","timestamp":1552146531000},"page":"657-671","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Oral levodopa rescues retinal morphology and visual function in a murine model of human albinism"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2573-9536","authenticated-orcid":false,"given":"Helena","family":"Lee","sequence":"first","affiliation":[{"name":"Clinical and Experimental Sciences, Faculty of Medicine Sir Henry Wellcome Laboratories, Southampton University Hospital University of Southampton Southampton UK"},{"name":"Eye Unit University Hospital Southampton NHS Foundation Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Scott","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences, Faculty of Medicine Sir Henry Wellcome Laboratories, Southampton University Hospital University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Griffiths","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences, Faculty of Medicine Sir Henry Wellcome Laboratories, Southampton University Hospital University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay E.","family":"Self","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences, Faculty of Medicine Sir Henry Wellcome Laboratories, Southampton University Hospital University of Southampton Southampton UK"},{"name":"Eye Unit University Hospital Southampton NHS Foundation Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lotery","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences, Faculty of Medicine Sir Henry Wellcome Laboratories, Southampton University Hospital University of Southampton Southampton UK"},{"name":"Eye Unit University Hospital Southampton NHS Foundation Trust Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0162835"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/13816819209087608"},{"key":"e_1_2_10_4_1","unstructured":"ARVO Statement for the use of animals in ophthalmic and vision research. 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