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A recent advance is the development of next\u2010generation BETi that are potent and display a favorable half\u2010life. Here, we tested the BETi, PLX51107, for immune\u2010based effects on tumor growth in BRAF V600E melanoma syngeneic models. PLX51107 delayed melanoma tumor growth and increased activated, proliferating, and functional CD8+ T cells in tumors leading to CD8+ T\u2010cell\u2010mediated tumor growth delay. PLX51107 decreased Cox2 expression, increased dendritic cells, and lowered PD\u2010L1, FasL, and IDO\u20101 expression in the tumor microenvironment. Importantly, PLX51107 delayed the growth of tumors that progressed on anti\u2010PD\u20101 therapy; a response associated with decreased Cox2 levels, decreased PD\u2010L1 expression on non\u2010immune cells, and increased intratumoral CD8+ T cells. Thus, next\u2010generation BETi represent a potential first\u2010line and secondary treatment strategy for metastatic melanoma by eliciting effects, at least in part, on antitumor CD8+ T cells.<\/jats:p>","DOI":"10.1111\/pcmr.12788","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T14:01:47Z","timestamp":1557237707000},"page":"687-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The next\u2010generation BET inhibitor, PLX51107, delays melanoma growth in a CD8\u2010mediated manner"],"prefix":"10.1111","volume":"32","author":[{"given":"Dan A.","family":"Erkes","sequence":"first","affiliation":[{"name":"Department of Cancer Biology Thomas Jefferson University Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Conroy O.","family":"Field","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology Thomas Jefferson 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