{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T17:27:03Z","timestamp":1784827623433,"version":"3.55.0"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008316","name":"Baden-W\u00fcrttemberg Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KR 4670\/2-1"],"award-info":[{"award-number":["KR 4670\/2-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KR 4670\/4-1"],"award-info":[{"award-number":["KR 4670\/4-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The tropical freshwater fish family Cichlidae is famous for its record\u2010breaking rates of speciation and diversity in colors and color patterns. Here, we sequenced the genome of the Lake Malawi cichlid <jats:italic>Melanochromis auratus<\/jats:italic> to study the genetic basis of an amelanistic morph of this species that lacks the typical melanic stripes and markings. Genome sequencing of the amelanistic and wild\u2010type morph revealed the loss of the second exon of the known pigmentation gene <jats:italic>oculocutaneous albinism II<\/jats:italic> (<jats:italic>oca2<\/jats:italic>), also known as <jats:italic>p(ink\u2010eyed dilution) gene<\/jats:italic> or <jats:italic>melanocyte\u2010specific transporter gene<\/jats:italic>. Additional genotyping confirms the complete association with this recessive Mendelian phenotype. The deletion results in a shorter transcript, lacking an acidic di\u2010leucine domain that is crucial for trafficking of the Oca2 protein to melanosomes. The fact that <jats:italic>oca2<\/jats:italic> is involved in a wide range of amelanistic morphs across vertebrates demonstrates its highly conserved function.<\/jats:p>","DOI":"10.1111\/pcmr.12799","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T12:15:03Z","timestamp":1558959303000},"page":"719-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Genome of the Malawi golden cichlid fish (<i>Melanochromis auratus<\/i>) reveals exon loss of <i>oca2<\/i> in an amelanistic morph"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-3114","authenticated-orcid":false,"given":"Claudius F.","family":"Kratochwil","sequence":"first","affiliation":[{"name":"Department of Biology, Zoology and Evolutionary Biology University of Konstanz Konstanz Germany"},{"name":"Zukunftskolleg University of Konstanz Konstanz Germany"},{"name":"International Max Planck Research School for Organismal Biology (IMPRS) Max Planck Institute for Ornithology Radolfzell Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4389-3075","authenticated-orcid":false,"given":"Sabine","family":"Urban","sequence":"additional","affiliation":[{"name":"Department of Biology, Zoology and Evolutionary Biology University of Konstanz Konstanz Germany"},{"name":"International Max Planck Research School for Organismal Biology (IMPRS) Max Planck Institute for Ornithology Radolfzell Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0888-8193","authenticated-orcid":false,"given":"Axel","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Biology, Zoology and Evolutionary Biology University of Konstanz Konstanz Germany"},{"name":"International Max Planck Research School for Organismal Biology (IMPRS) Max Planck Institute for Ornithology Radolfzell Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.4080"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04543"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12861-017-0146-0"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2148-7-74"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1673574"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.104.030494"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genom-090413-025412"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0077647"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2018.03.014"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao6809"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201400142"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12861-017-0157-x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-813316-3.00005-2"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.055"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003561"},{"key":"e_1_2_5_17_1","volume-title":"R: A language and environment for statistical computing","author":"R Development Core Team","year":"2019"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/361072a0"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174705"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep17118"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0043-9"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-5-51"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6149"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12409"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-06-0509"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E08-07-0710"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12861-018-0166-4"}],"container-title":["Pigment Cell &amp; 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