{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T18:19:28Z","timestamp":1781806768844,"version":"3.54.5"},"reference-count":89,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Tissue\u2010resident memory T (T<jats:sub>RM<\/jats:sub>) cells are abundant in the memory T cell pool and remain resident in peripheral tissues, such as the skin, where they act as alarm sensors or cytotoxic killers. T<jats:sub>RM<\/jats:sub> cells persist long after the pathogen is eliminated and can respond rapidly upon reinfection with the same antigen. When aberrantly activated, skin\u2010located T<jats:sub>RM<\/jats:sub> cells have a profound role in various skin disorders, including vitiligo and melanoma. Autoreactive T<jats:sub>RM<\/jats:sub> cells are present in human lesional vitiligo skin and mouse models of vitiligo, which suggests that targeting these cells could be effective as a durable treatment strategy for vitiligo. Furthermore, emerging evidence indicates that induction of melanoma\u2010reactive T<jats:sub>RM<\/jats:sub> cells is needed to achieve effective protection against tumor growth. This review highlights seminal reports about skin\u2010resident T cells, focusing mainly on their role in the context of vitiligo and melanoma, as well as their potential as therapeutic targets in both diseases.<\/jats:p>","DOI":"10.1111\/pcmr.12803","type":"journal-article","created":{"date-parts":[[2019,6,23]],"date-time":"2019-06-23T10:49:38Z","timestamp":1561286978000},"page":"612-622","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Skin\u2010resident memory T cells as a potential new therapeutic target in vitiligo and melanoma"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3376-6734","authenticated-orcid":false,"given":"Marcella","family":"Willemsen","sequence":"first","affiliation":[{"name":"Department of Dermatology and Netherlands Institute for Pigment Disorders Amsterdam University Medical Centers, University of Amsterdam, Cancer Center Amsterdam Amsterdam Infection 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