{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:38:17Z","timestamp":1771580297001,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011105","name":"National University Cancer Institute, Singapore","doi-asserted-by":"publisher","award":["P30-CA076292"],"award-info":[{"award-number":["P30-CA076292"]}],"id":[{"id":"10.13039\/501100011105","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011105","name":"National University Cancer Institute, Singapore","doi-asserted-by":"publisher","award":["Skin SPORE P50CA168536-01A1"],"award-info":[{"award-number":["Skin SPORE P50CA168536-01A1"]}],"id":[{"id":"10.13039\/501100011105","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Current management of locoregional and oligometastatic melanoma is typically with surgery; however, some patients are unable to undergo resection due to location\/size of their tumors and\/or the anticipated morbidity of the surgery. While there are currently no established guidelines for neoadjuvant therapy in melanoma, neoadjuvant BRAF\u2010targeted therapy may make resection more feasible. A retrospective analysis was conducted of 23 patients with BRAFV600\u2010mutant, stage III\/IV melanoma treated with BRAF\u2010targeted therapy prior to surgery, with no adjuvant treatment. Surgical specimens, preoperative imaging, and clinical outcomes were evaluated. Results: Ten of 23 patients (44%) attained a pathologic complete response (pCR), with no correlation between RECIST response based on preoperative imaging and pathologic response. After a median of 43\u2010month follow\u2010up, only 1 patient (10%) with a pCR recurred, while 8 of 13 (62%) patients without a pCR recurred. Patients with a pCR had significantly improved relapse\u2010free (RFS) and overall survival (OS) compared to patients with residual tumor. Neoadjuvant BRAF\u2010targeted therapy is associated with a high pCR rate in patients with stage III\u2010IV melanoma, which may correlate with improved RFS and OS.<\/jats:p>","DOI":"10.1111\/pcmr.12813","type":"journal-article","created":{"date-parts":[[2019,7,22]],"date-time":"2019-07-22T15:09:10Z","timestamp":1563808150000},"page":"86-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Neoadjuvant BRAF\u2010targeted therapy in regionally advanced and oligometastatic melanoma"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2307-7030","authenticated-orcid":false,"given":"Zeynep","family":"Eroglu","sequence":"first","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Eatrides","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2530-2756","authenticated-orcid":false,"given":"Syeda Mahrukh Hussnain","family":"Naqvi","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youngchul","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeani","family":"Rich","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nalan Akgul","family":"Babacan","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew S.","family":"Brohl","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Markowitz","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amod","family":"Sarnaik","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Zager","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikhil I.","family":"Khushalani","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vernon K.","family":"Sondak","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology Moffitt Cancer Center Tampa Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30015-9"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0197-1"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30016-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30122-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0198-0"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008390-199812000-00010"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30142-6"},{"issue":"22","key":"e_1_2_9_9_1","first-page":"bcr2012007034","article-title":"Inoperable bulky melanoma responds to neoadjuvant therapy with vemurafenib","volume":"2012","author":"Fadaki N.","year":"2012","journal-title":"Case Reports"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10186"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.09.052"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.45.3845"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt.12.62"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.0958"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.5344"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1708539"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30331-6"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60898-4"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/794239"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.15_suppl.9503"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.35.15_suppl.9581"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.05.2498"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000083"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1412690"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30151-2"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000145"},{"key":"e_1_2_9_27_1","first-page":"21","article-title":"Dacarbazine\u2010based chemotherapy for metastatic melanoma: Thirty\u2010year experience overview","volume":"19","author":"Serrone L.","year":"2000","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/CMR.0000000000000214"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087705"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy226"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24744"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12813","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pcmr.12813","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12813","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T10:12:25Z","timestamp":1693995145000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,12]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1111\/pcmr.12813"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12813","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,12]]},"assertion":[{"value":"2019-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}