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The distribution of naevi, a major risk factor for melanoma, at different body sites also varies according to sex in childhood. Using naevus counts at different body sites in 492 unrelated adults from both sexes, we observed that women have an increased number of naevi on the lower limbs compared to men (<jats:italic>p<\/jats:italic>\u00a0=\u00a08.5\u00a0\u00d7\u00a010<jats:sup>\u22125<\/jats:sup>), showing that a high naevus count on this site persists from childhood throughout life. Then, using data from 3,232 twins, we observed, in women, the lowest naevus count heritability on the trunk (26%), and the highest on the lower limbs (69%). Finally, we showed that, in 2,864 women, six genomic loci previously associated with both naevus count and melanoma risk (<jats:italic>IRF4<\/jats:italic>, <jats:italic>DOCK8<\/jats:italic>, <jats:italic>MTAP<\/jats:italic>, <jats:italic>9q31.2<\/jats:italic>, <jats:italic>KITLG<\/jats:italic> and <jats:italic>PLA2G6<\/jats:italic>) have an effect on naevus count that is body site\u2010specific, but whose effect sizes are predominantly stronger on the lower limbs. Sex\u2010specific genetic influence on naevus count at different sites may explain differences in site\u2010specific melanoma incidence as well as prognosis between sexes.<\/jats:p>","DOI":"10.1111\/pcmr.12820","type":"journal-article","created":{"date-parts":[[2019,8,12]],"date-time":"2019-08-12T14:29:47Z","timestamp":1565620187000},"page":"326-333","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Body site\u2010specific genetic effects influence naevus count distribution in women"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4144-2019","authenticated-orcid":false,"given":"Alessia","family":"Visconti","sequence":"first","affiliation":[{"name":"Department of Twin Research &amp; Genetic Epidemiology King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-1406","authenticated-orcid":false,"given":"Simone","family":"Ribero","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, Section of Dermatology University of Turin Turin Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5881-809X","authenticated-orcid":false,"given":"Marianna","family":"Sanna","sequence":"additional","affiliation":[{"name":"Department of Twin Research &amp; Genetic Epidemiology King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim D.","family":"Spector","sequence":"additional","affiliation":[{"name":"Department of Twin Research &amp; Genetic Epidemiology King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8750-4150","authenticated-orcid":false,"given":"Veronique","family":"Bataille","sequence":"additional","affiliation":[{"name":"Department of Twin Research &amp; Genetic Epidemiology King's College London London UK"},{"name":"Department of Dermatology West Herts NHS Trust Herts UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5646-1004","authenticated-orcid":false,"given":"Mario","family":"Falchi","sequence":"additional","affiliation":[{"name":"Department of Twin Research &amp; Genetic Epidemiology King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,8,25]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1375\/twin.4.6.464"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.2003.13.12"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2013.05.031"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20812"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1086\/522036"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-07-0453"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2008.190"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.05.017"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06649-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.410"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1994.tb13106.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1990.01670280050008"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2004.10.015"},{"issue":"10","key":"e_1_2_8_15_1","first-page":"2492","article-title":"Primary cutaneous melanoma","volume":"75","author":"Garbe C.","year":"1995","journal-title":"Prognostic Classification of Anatomic Location. 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