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We made the surprising observation that in a drastically changed environment, white and black phenotypes are reversible since Caucasian skin grafted onto nude mice can become black with all black phenotypic characteristics. Black xenografts differed essentially from other grafts by the levels of epidermal FGF\u20102 and keratin 5. In vitro analysis confirmed that FGF\u20102 directly regulates keratin 5. Interestingly, this phenomenon may be involved in human pathology. Keratin 5 mutations in Dowling\u2013Degos Disease (DDD) have already been associated with the pheomelanosome\u2013eumelanosome transition. In a DDD patient, keratin 5 was expressed in the basal and spinous layers, as observed in black xenografts. Furthermore, in a common age\u2010related hyperpigmentation disorder like senile lentigo (SL), keratin 5 distribution is also altered. In conclusion, modulation of keratin 5 expression and distribution either due to mutations or factors may account for the development of pigmentary disorders.<\/jats:p>","DOI":"10.1111\/pcmr.12844","type":"journal-article","created":{"date-parts":[[2019,11,6]],"date-time":"2019-11-06T10:56:02Z","timestamp":1573037762000},"page":"435-445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Epidermal keratin 5 expression and distribution is under dermal influence"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-5684","authenticated-orcid":false,"given":"Muriel","family":"Cario","sequence":"first","affiliation":[{"name":"INSERM U1035 Bordeaux France"},{"name":"BMGIC Universite de Bordeaux Bordeaux France"},{"name":"National Reference Center for Rare skin Diseases Bordeaux University Hospitals Bordeaux France"},{"name":"AquiDerm Bordeaux 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