{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:39:08Z","timestamp":1792669148319,"version":"4.5.0"},"reference-count":98,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,19]],"date-time":"2020-01-19T00:00:00Z","timestamp":1579392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In February 2018, the Melanoma Research Foundation and the Moffitt Cancer Center hosted the Second Summit on Melanoma Central Nervous System Metastases in Tampa, Florida. The meeting included investigators from multiple academic centers and disciplines. A consensus summary of the progress and challenges in melanoma parenchymal brain metastases was published (Eroglu et al., <jats:italic>Pigment Cell &amp; Melanoma Research<\/jats:italic>, 2019, 32, 458). Here, we will describe the current state of basic, translational, clinical research, and therapeutic management, for melanoma patients with leptomeningeal disease. We also outline key challenges and barriers to be overcome to make progress in this deadly disease.<\/jats:p>","DOI":"10.1111\/pcmr.12861","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T04:08:50Z","timestamp":1578542930000},"page":"527-541","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4530-7765","authenticated-orcid":false,"given":"Isabella C.","family":"Glitza","sequence":"first","affiliation":[{"name":"Department of Melanoma Medical Oncology UT MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1089-9307","authenticated-orcid":false,"given":"Keiran S. M.","family":"Smalley","sequence":"additional","affiliation":[{"name":"Melanoma Research Center of Excellence H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscilla K.","family":"Brastianos","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Oncology Massachusetts General Hospital Boston MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0977-0912","authenticated-orcid":false,"given":"Michael A.","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Melanoma Medical Oncology UT MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"McCutcheon","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery UT MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James K. C.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology &amp; Tumor Biology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran A.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John A.","family":"Arrington","sequence":"additional","affiliation":[{"name":"Head of Neuroradiology Section Department of Radiology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brittany R.","family":"Evernden","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology &amp; Tumor Biology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inna","family":"Smalley","sequence":"additional","affiliation":[{"name":"Department of Tumor Biology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2307-7030","authenticated-orcid":false,"given":"Zeynep","family":"Eroglu","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Khushalani","sequence":"additional","affiliation":[{"name":"Department of Cutaneous Oncology H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Margolin","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology and Therapeutics Research City of Hope National Medical Center Duarte CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harriet","family":"Kluger","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Yale Cancer Center New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B.","family":"Atkins","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Georgetown University Medical Center Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Tawbi","sequence":"additional","affiliation":[{"name":"Department of Melanoma Medical Oncology UT MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Boire","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology Memorial Sloan Kettering New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3756-8594","authenticated-orcid":false,"given":"Peter","family":"Forsyth","sequence":"additional","affiliation":[{"name":"Department of Neuro\u2010Oncology &amp; Tumor Biology H. 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