{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:44:04Z","timestamp":1790253844272,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T00:00:00Z","timestamp":1591228800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The genetic anomalies associated with the agminated variant of Spitz nevus have so far been limited to\n                    <jats:italic>HRAS<\/jats:italic>\n                    G13R mutations, especially when arising within a nevus spilus. A previous report exposed the case of a man with a giant pigmented macule involving his upper right limb and trunk. Since childhood, Spitz nevi have been periodically arising, within the pigmented area. The histopathology of several lesions displayed the usual criteria of junctional, compound, or intradermal Spitz nevi with a diversity of cytomorphological and architectural features. Some lesions spontaneously regressed. Genetic studies confirmed in three lesions an identical translocation involving\n                    <jats:italic>TRPM1<\/jats:italic>\n                    ,\n                    <jats:italic>PUM1<\/jats:italic>\n                    , and\n                    <jats:italic>LCK<\/jats:italic>\n                    . No mutations in\n                    <jats:italic>HRAS<\/jats:italic>\n                    ,\n                    <jats:italic>NRAS<\/jats:italic>\n                    ,\n                    <jats:italic>BRAF<\/jats:italic>\n                    , or other known fusion genes linked to Spitz nevus were detected.\n                    <jats:italic>LCK<\/jats:italic>\n                    break\u2010apart fluorescence in situ hybridization confirmed the rearrangement was present not only in the melanocytic proliferation but also in the surrounding non\u2010spitzoid melanocytes. This report expands the list of genetic alterations involved both in giant congenital macules and in agminated Spitz nevi, and also extends the concept of mosaicism in melanocytes to gene translocations.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.12884","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T17:09:10Z","timestamp":1589044150000},"page":"767-772","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Novel three\u2010way complex rearrangement of\n                    <i>TRPM1\u2010PUM1<\/i>\n                    \u2010\n                    <i>LCK<\/i>\n                    in a case of agminated Spitz nevi arising in a giant congenital hyperpigmented macule"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4165-1809","authenticated-orcid":false,"given":"Keisuke","family":"Goto","sequence":"first","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital Tokyo Japan"},{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital Nagaizumi Japan"},{"name":"Department of Diagnostic Pathology and Cytology Osaka International Cancer Institute Osaka Japan"},{"name":"Department of Dermatology Hyogo Cancer Center Akashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pissaloux","sequence":"additional","affiliation":[{"name":"Department of Biopathology Center L\u00e9on B\u00e9rard Lyon France"},{"name":"INSERM 1052 CNRS 5286 Centre L\u00e9on B\u00e9rard Cancer Research Center of Lyon Equipe Labellis\u00e9e Ligue contre le Cancer Universit\u00e9 de Lyon Universit\u00e9 Claude Bernard Lyon 1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Durand","sequence":"additional","affiliation":[{"name":"MEDIPATH Grabels France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Tirode","sequence":"additional","affiliation":[{"name":"Department of Biopathology Center L\u00e9on B\u00e9rard Lyon France"},{"name":"INSERM 1052 CNRS 5286 Centre L\u00e9on B\u00e9rard Cancer Research Center of Lyon Equipe Labellis\u00e9e Ligue contre le Cancer Universit\u00e9 de Lyon Universit\u00e9 Claude Bernard Lyon 1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Guillot","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saint Eloi University Hospital CHU Montpellier Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"de la Fouchardi\u00e8re","sequence":"additional","affiliation":[{"name":"Department of Biopathology Center L\u00e9on B\u00e9rard Lyon France"},{"name":"INSERM 1052 CNRS 5286 Centre L\u00e9on B\u00e9rard Cancer Research Center of Lyon Equipe Labellis\u00e9e Ligue contre le Cancer Universit\u00e9 de Lyon Universit\u00e9 Claude Bernard Lyon 1 Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2009.10.013"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12785"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12605"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1470.2001.1861991.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.4.1232.1232"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09460"},{"issue":"3","key":"e_1_2_6_8_1","first-page":"345","article-title":"Spitz juvenile nevomatosis: Profuse linear form [in French]","volume":"115","author":"Guillot B.","year":"1988","journal-title":"Annales de Dermatologie et de 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