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Previous studies proved that CD147 plays a crucial function in melanoma cell metastasis and invasion through matrix metalloproteinase 9 (MMP\u20109) expression; however, the details of how CD147 regulates MMP\u20109 expression remain elusive. In this study, we demonstrated that CD147 and NFAT1 are overexpressed in the tissues of patients with primary and metastatic melanoma, which has shown a positive correlation. Further, we observed that CD147 regulates NFAT1 activation through the [Ca<jats:sup>2+<\/jats:sup>]i\u2010calcineurin pathway. Knockdown of NFAT1 significantly suppresses melanoma metastasis, and we demonstrated that CD147 affects melanoma metastasis in an NFAT1\u2010dependent manner. Moreover, we verified that NFAT1 directly binds to MMP\u20109 promoter. Inhibition of CD147 expression significantly abrogates MMP\u20109 promoter luciferase gene reporter activity as well as NFAT1 association with MMP\u20109 promoter. Taken together, this study demonstrated that CD147 affects MMP\u20109 expression through regulating NFAT1 activity and provided a novel mechanism by which NFAT1 contributes to melanoma metastasis through the regulation of MMP\u20109.<\/jats:p>","DOI":"10.1111\/pcmr.12886","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T19:37:40Z","timestamp":1588016260000},"page":"731-743","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["CD147 regulates melanoma metastasis via the NFAT1\u2010MMP\u20109 pathway"],"prefix":"10.1111","volume":"33","author":[{"given":"Nian","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University Changsha China"},{"name":"Hunan Key Laboratory of Skin Cancer and Psoriasis Changsha China"},{"name":"Human Engineering Research Center of Skin Health and Disease Changsha 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