{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T10:42:50Z","timestamp":1780569770583,"version":"3.54.1"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["KAKENHI \/ JP16K10123"],"award-info":[{"award-number":["KAKENHI \/ JP16K10123"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Racemic RS\u20104\u2010(4\u2010hydroxyphenyl)\u20102\u2010butanol (rhododendrol; trade name: Rhododenol [RD]), which is used in topical skin\u2010lightening cosmetics, was unexpectedly reported in Japan to induce leukoderma or vitiligo called RD\u2010induced leukoderma (RIL) after repeated application. To our knowledge, no studies have investigated chemical\u2010induced vitiligo pathogenesis on a genome\u2010wide scale. Here, we conducted a genome\u2010wide association study (GWAS) for 147 cases and 112 controls. <jats:italic>CDH13<\/jats:italic>, encoding a glycosylphosphatidylinositol\u2010anchored protein called T\u2010cadherin (T\u2010cad), was identified as the strongest RIL susceptibility gene. RD sensitivity was remarkably increased by T\u2010cad knockdown in cultured normal human melanocytes. Furthermore, we confirmed tyrosinase upregulation and downregulation of the anti\u2010apoptotic molecules (BCL\u20102 and BCL\u2010XL), suggesting that T\u2010cad is associated with RD via tyrosinase or apoptotic pathway regulation. Finally, monobenzyl ether of hydroquinone sensitivity also tended to increase with T\u2010cad knockdown, suggesting that the T\u2010cad could be a candidate susceptibility gene for RIL and other chemical\u2010induced vitiligo forms. This is the first GWAS for chemical\u2010induced vitiligo, and it could be a useful model for studying the disease's genetic aspects.<\/jats:p>","DOI":"10.1111\/pcmr.12904","type":"journal-article","created":{"date-parts":[[2020,6,19]],"date-time":"2020-06-19T02:33:58Z","timestamp":1592534038000},"page":"826-833","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Genome\u2010wide association study identifies <i>CDH13<\/i> as a susceptibility gene for rhododendrol\u2010induced leukoderma"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7366-3233","authenticated-orcid":false,"given":"Ken","family":"Okamura","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Yamagata University Yamagata 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