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Here, we describe the characterization\u00a0of a panel of 102 cell lines from metastatic melanomas (the NZM lines), including using whole\u2010exome and RNA sequencing to analyse genetic variants and gene expression changes in a subset of this panel.\u00a0Lines possessing all major melanoma genotypes were identified, and hierarchical clustering of gene expression profiles revealed four broad subgroups of cell lines. Immunogenotyping identified a range of HLA haplotypes as well as expression of neoantigens\u00a0and\u00a0cancer\u2013testis antigens in the lines. Together, these characteristics make the NZM panel a valuable\u00a0resource for cell\u2010based, immunological\u00a0and xenograft studies to better understand the diversity of melanoma biology and the responses of melanoma to therapeutic interventions.<\/jats:p>","DOI":"10.1111\/pcmr.12908","type":"journal-article","created":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T12:00:29Z","timestamp":1592827229000},"page":"136-143","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma"],"prefix":"10.1111","volume":"34","author":[{"given":"Khanh B.","family":"Tran","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine and Pathology University of Auckland Auckland New Zealand"},{"name":"Maurice Wilkins Centre for Molecular Biodiscovery 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