{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T15:36:09Z","timestamp":1750779369440,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005897","name":"Soci\u00e9t\u00e9 Fran\u00e7aise de Dermatologie et de Pathologie Sexuellement Transmissible","doi-asserted-by":"publisher","award":["Convention n\u00b03 \u2010AO septembre 2018"],"award-info":[{"award-number":["Convention n\u00b03 \u2010AO septembre 2018"]}],"id":[{"id":"10.13039\/501100005897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Systemic sclerosis (SSc) is a severe disease whose pathophysiology remains partly unknown, combining autoimmune, vascular, and fibrotic features. Recently, we evidenced a link between vasculopathy and pigmentary changes in SSc. CCN3 (NOV) is a matricellular protein implicated in both angiogenesis and pigmentation regulation, in particular melanocyte adhesion to the basal layer. We decided to study CCN3 expression in SSc epidermis. We show that in SSc patients with pigmentary changes compared to patients with normal pigmentation, CCN3 is specifically downregulated in situ in melanocytes and upregulated in keratinocytes. Moreover, the number of melanocytes is significantly decreased in SSc patients with a disease duration of more than 5\u00a0years compared to the other patients. Altogether, our findings could provide new insights on the mechanisms of pigmentary changes in SSc patients, as well as treatment adaptation in a personalized manner.<\/jats:p>","DOI":"10.1111\/pcmr.12912","type":"journal-article","created":{"date-parts":[[2020,7,7]],"date-time":"2020-07-07T06:59:55Z","timestamp":1594105195000},"page":"895-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dysregulation of CCN3 (NOV) expression in the epidermis of systemic sclerosis patients with pigmentary changes"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6528-6092","authenticated-orcid":false,"given":"Pauline","family":"Henrot","sequence":"first","affiliation":[{"name":"Inserm BMGIC UMR1035 University of Bordeaux Bordeaux France"},{"name":"Department of Rheumatology National Reference Center for Systemic Autoimmune Rare Diseases Hopital Pellegrin, place Am\u00e9lie Raba\u2010L\u00e9on Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Pain","sequence":"additional","affiliation":[{"name":"Inserm BMGIC UMR1035 University of Bordeaux Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0928-8608","authenticated-orcid":false,"given":"Alain","family":"Ta\u00efeb","sequence":"additional","affiliation":[{"name":"Inserm BMGIC UMR1035 University of Bordeaux Bordeaux France"},{"name":"Department of Dermatology and Pediatric Dermatology National Center for Rare Skin Disorders H\u00f4pital Saint Andr\u00e9 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8045-0180","authenticated-orcid":false,"given":"Marie\u2010Elise","family":"Truchetet","sequence":"additional","affiliation":[{"name":"Department of Rheumatology National Reference Center for Systemic Autoimmune Rare Diseases Hopital Pellegrin, place Am\u00e9lie Raba\u2010L\u00e9on Bordeaux France"},{"name":"CNRS Immunoconcept UMR 5164 University of Bordeaux Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0462-5684","authenticated-orcid":false,"given":"Muriel","family":"Cario","sequence":"additional","affiliation":[{"name":"Inserm BMGIC UMR1035 University of Bordeaux Bordeaux France"},{"name":"Department of Dermatology and Pediatric Dermatology National Center for Rare Skin Disorders H\u00f4pital Saint Andr\u00e9 Bordeaux France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,20]]},"reference":[{"key":"e_1_2_1_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2008.03672.x"},{"key":"e_1_2_1_5_3_1","doi-asserted-by":"publisher","DOI":"10.4172\/2376-0427.1000239"},{"key":"e_1_2_1_5_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00210.x"},{"key":"e_1_2_1_5_5_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200602132"},{"key":"e_1_2_1_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0806188"},{"key":"e_1_2_1_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.11.026"},{"issue":"20","key":"e_1_2_1_5_8_1","first-page":"31204","article-title":"Is hyperpigmentation in systemic sclerosis a perivascular dermal tattoo?","volume":"0022","author":"Henrot P.","year":"2020","journal-title":"Journal of Investigative Dermatology"},{"key":"e_1_2_1_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13806"},{"key":"e_1_2_1_5_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033281"},{"key":"e_1_2_1_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.033"},{"key":"e_1_2_1_5_12_1","first-page":"1912","article-title":"Increased pigmentation in scleroderma","volume":"23","author":"Pope J. 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