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This review describes the current understanding of the most commonly prescribed antihypertensives and their associations with melanoma. The literature demonstrates that diuretics, specifically hydrochlorothiazide and indapamide, may increase the risk of melanoma. While there is no evidence that antihypertensives have a role in melanoma prevention, non\u2010selective \u03b2\u2010blocker therapy has been associated with a decreased risk of disease progression and recurrence and may also improve outcomes in patients undergoing immunotherapy. In addition, experimental studies reveal that angiotensin\u2010converting enzyme inhibitors, angiotensin receptor blockers, and calcium channel blockers have anti\u2010tumor effects, meriting further study.<\/jats:p>","DOI":"10.1111\/pcmr.12918","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T22:55:32Z","timestamp":1596668132000},"page":"806-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antihypertensives and melanoma: An updated review"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3651-1019","authenticated-orcid":false,"given":"Natalie M.","family":"Williams","sequence":"first","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis T.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine  University of Miami\/Jackson Memorial Hospital Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor A.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine  University of Miami\/Jackson Memorial Hospital Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyvan","family":"Nouri","sequence":"additional","affiliation":[{"name":"Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12020391"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2018.15"},{"issue":"6","key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"2904","DOI":"10.4049\/jimmunol.133.6.2904","article-title":"The interference of T cell activation by calcium channel blocking agents","volume":"133","author":"Birx D. 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