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It was recently revealed that distinct cAMP signaling pathways regulate pigmentation by either altering pigment gene expression or the pH of melanosomes. In the context of melanoma, many studies report seemingly contradictory roles for cAMP in tumorigenesis. For example, cAMP signaling has been implicated in both cancer promotion and suppression, as well as both therapy resistance and sensitization. This conundrum in the field may be explained by the fact that cAMP signals in discrete microdomains and each microdomain can mediate differential cellular functions. Here, we review the role of cAMP signaling microdomains in benign melanocyte biology, focusing on pigmentation, and in melanomagenesis.<\/jats:p>","DOI":"10.1111\/pcmr.12920","type":"journal-article","created":{"date-parts":[[2020,8,10]],"date-time":"2020-08-10T22:59:07Z","timestamp":1597100347000},"page":"28-43","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Cyclic adenosine monophosphate (cAMP) signaling in melanocyte pigmentation and melanomagenesis"],"prefix":"10.1111","volume":"34","author":[{"given":"Jakyung","family":"Bang","sequence":"first","affiliation":[{"name":"Department of Dermatology Joan and Sanford I. Weill Medical College of Cornell University New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5882-0189","authenticated-orcid":false,"given":"Jonathan H.","family":"Zippin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Joan and Sanford I. 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