{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:55:34Z","timestamp":1762102534267,"version":"3.40.5"},"reference-count":45,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100008667","name":"National Cancer Research Institute","doi-asserted-by":"publisher","award":["RO1 CA204430"],"award-info":[{"award-number":["RO1 CA204430"]}],"id":[{"id":"10.13039\/100008667","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pigmentation abnormalities are reported in the spectrum of phenotypes associated with aging and in patients with mitochondrial DNA depletion syndrome (MDS). Yet, a relevant animal model that mimics these effects and would allow us to evaluate the detrimental aspects of mtDNA depletion on melanocyte function has not been described. Here, we characterize the pigmentary changes observed in the ears of a mtDNA\u2010depleter mouse, which phenotypically includes accentuation of the peri\u2010adnexal pseudonetwork, patchy hyper\u2010 and hypopigmentation, and reticular pigmentation. Histologically, these mice show increased epidermal pigmentation with patchy distribution, along with increased and highly dendritic melanocytes. These mtDNA\u2010depleter mice mimic aspects of the cutaneous, pigmentary changes observed in humans with age\u2010related senile lentigines as well as MDS. We suggest that this mouse model can serve as a novel resource for future interrogations of how mitochondrial dysfunction contributes to pigmentary skin disorders. The mtDNA\u2010depleter mouse model also serves as a useful tool to identify novel agents capable of treating pigmentary changes associated with age\u2010related mitochondrial dysfunction in humans.<\/jats:p>","DOI":"10.1111\/pcmr.12921","type":"journal-article","created":{"date-parts":[[2020,8,28]],"date-time":"2020-08-28T04:17:49Z","timestamp":1598588269000},"page":"179-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Mitochondrial DNA\u2010depleter mouse as a model to study human pigmentary skin disorders"],"prefix":"10.1111","volume":"34","author":[{"given":"Kyrene M.","family":"Villavicencio","sequence":"first","affiliation":[{"name":"Department of Biology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noha","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Genetics, School of Medicine University of Alabama at Birmingham Birmingham AL USA"},{"name":"Department of Dermatology Zagazig University Zagazig Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6223-1611","authenticated-orcid":false,"given":"Melissa L.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Biology University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keshav K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Genetics, School of Medicine University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.037168"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-4039fje"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2011.407"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2004.00131.x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00337.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.12207"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.1998.00099.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.103.2.428"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(01)68105-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.01.017"},{"key":"e_1_2_6_12_1","first-page":"277","article-title":"Lentigo senilis. 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