{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:46:41Z","timestamp":1790898401054,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plastic adaptation to match the skin colour to the surrounding is key to survival. Two biological responses in skin colour are associated with background adaptation. A fast \u201cphysiological response\u201d that aggregates\/disperses the pigment organelles of skin chromatophores, and a slow \u201cmorphological response\u201d that alters the type and\/or density of pigment cells in the skin. Both responses are linked by unknown mechanisms. In this review, we discuss the role in skin colour regulation of two molecules that form part of a hypothalamic\u2010hypophyseal pathway unique to teleosts, melanin\u2010concentrating hormone \u201clike\u201d (MCHL) (previously known as MCH), and somatolactin. MCHL neurons project to the neurohypophysis and to the pars intermedia pituitary, where they interact with somatolactin\u2010expressing cells. With a white background MCHL is released into the circulation to induce rapid melanosome aggregation and skin lightening. Somatolactin is also a fish\u2010specific peptide whose expression and secretion are altered in organisms adapted chronically to white\/black backgrounds, and that regulates morphological pigmentation. We discuss the evidence for a model whereby in teleosts, MCHL and somatolactin provide the previously unknown link between physiological and morphological pigmentation.<\/jats:p>","DOI":"10.1111\/pcmr.12924","type":"journal-article","created":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T05:42:31Z","timestamp":1600666951000},"page":"564-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Melanin\u2010concentrating hormone like and somatolactin. A teleost\u2010specific hypothalamic\u2010hypophyseal axis system linking physiological and morphological pigmentation"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6154-9513","authenticated-orcid":false,"given":"Gabriel E.","family":"Bertolesi","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Anatomy Hotchkiss Brain Institute Alberta Children's Hospital Research Institute Cumming School of Medicine University of Calgary  Calgary AB Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"McFarlane","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Anatomy Hotchkiss Brain Institute Alberta Children's Hospital Research Institute Cumming School of Medicine University of Calgary  Calgary AB 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