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IFN\u03b3 is the central cytokine driving disease, but the role of type I IFN in vitiligo remains unclear. We investigated the functional role of type I IFN during vitiligo progression using two different mouse models: one induced with a vaccinia virus (VV) vaccine and one induced with dendritic cells to prime autoimmune T cells. Induction of vitiligo by VV in IFNaR\u2010deficient mice led to the development of severe vitiligo compared with wild\u2010type (WT) mice and was characterized by a significantly enhanced effector CD8<jats:sup>+<\/jats:sup> T\u2010cell response. Severe vitiligo in this model was a result of VV persistence, because exacerbation of disease in IFNaR\u2010deficient mice was not observed when antigen\u2010pulsed dendritic cells were used to induce vitiligo instead of virus. Treatment of B16F10 melanoma\u2010inoculated mice with VV vaccine therapy also induced a significantly enhanced anti\u2010tumor response in IFNaR\u2010deficient mice compared with WT. These results not only help define the pathways responsible for vitiligo progression but also suggest that blockade of type I IFNs following administration of a VV vaccine may provide increased immunogenicity and efficacy for melanoma immunotherapy.<\/jats:p>","DOI":"10.1111\/pcmr.12935","type":"journal-article","created":{"date-parts":[[2020,10,11]],"date-time":"2020-10-11T05:16:20Z","timestamp":1602393380000},"page":"683-695","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Type I interferon signaling limits viral vector priming of CD8<sup>+<\/sup> T cells during initiation of vitiligo and melanoma immunotherapy"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3698-9848","authenticated-orcid":false,"given":"Rebecca L.","family":"Riding","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1589-6770","authenticated-orcid":false,"given":"Jillian M.","family":"Richmond","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8847-0063","authenticated-orcid":false,"given":"Keitaro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Massachusetts Medical School  Worcester MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.11.061"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00032.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02719.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.767"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12219"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00322"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196406)17:6<708:aid-cncr2820170604>3.0.co;2-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.5.821"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.10.6634"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90745"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1968.tb12282.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-019-0805-8"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/104303403322319426"},{"issue":"19","key":"e_1_2_8_15_1","first-page":"4955","article-title":"Modified vaccinia virus Ankara for delivery of human tyrosinase as melanoma\u2010associated antigen: Induction of tyrosinase\u2010 and melanoma\u2010specific human leukocyte antigen A*0201\u2010restricted cytotoxic T cells in vitro and in vivo","volume":"59","author":"Drexler I.","year":"1999","journal-title":"Cancer Research"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17011-z"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.07.039"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.08.063"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.08.016"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2009.04443.x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2017.01.001"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.463"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.463"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.05.018"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1003466"},{"issue":"2","key":"e_1_2_8_26_1","first-page":"351","article-title":"Identification of differentiation antigens of melanoma and melanocytes by mouse and human monoclonal antibodies","volume":"16","author":"Houghton A. 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