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Mutations in\n                    <jats:italic>Tyr<\/jats:italic>\n                    might result in non\u2010functional Tyr protein and, consequently, loss of pigment production. This is a rare genetic condition, known as albinism, described for most animal species and one of the most obvious and simple phenotypes to investigate in model organisms. Mutations in the orthologous human\n                    <jats:italic>TYR<\/jats:italic>\n                    gene are associated with oculocutaneous albinism type 1 (OCA1). Over the last thirty years, the mouse\n                    <jats:italic>Tyr<\/jats:italic>\n                    locus has been studied as a paradigm for how genes and expression domains are organized and regulated in mammalian genomes. This review summarizes the major findings and experimental strategies used, from the production of conventional transgenic mice to the latest CRISPR\u2010Cas9 genome\u2010edited animals. The main conclusion inferred from all of these studies, which extends beyond the analysis of the mouse\n                    <jats:italic>Tyr<\/jats:italic>\n                    locus, is the relevance of analyzing non\u2010coding regulatory DNA elements in their natural chromosomal environment, and not only as randomly inserted transgenes. Further, the identification of evolutionary conserved regulatory sequences might highlight new vulnerable sites in the human\n                    <jats:italic>TYR<\/jats:italic>\n                    gene, whose mutations could also be associated with albinism.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.12942","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T22:44:48Z","timestamp":1603493088000},"page":"212-221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["The structure and function of the mouse tyrosinase locus"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5014-0499","authenticated-orcid":false,"given":"Davide","family":"Seruggia","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology National Centre for Biotechnology (CNB\u2010CSIC) Madrid Madrid Spain"},{"name":"CIBERER\u2010ISCIII Madrid Spain"},{"name":"Division of Hematology\/Oncology Boston Children's Hospital Harvard Medical School Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Josa","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology National Centre for Biotechnology (CNB\u2010CSIC) Madrid Madrid Spain"},{"name":"CIBERER\u2010ISCIII Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almudena","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology National Centre for Biotechnology (CNB\u2010CSIC) Madrid Madrid Spain"},{"name":"CIBERER\u2010ISCIII Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3941-1176","authenticated-orcid":false,"given":"Lluis","family":"Montoliu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology National Centre for Biotechnology (CNB\u2010CSIC) Madrid Madrid Spain"},{"name":"CIBERER\u2010ISCIII Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.07.030"},{"key":"e_1_2_9_3_1","first-page":"61","volume-title":"The Heredity of Coat Color in Mice","author":"Allen G. 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