{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T01:16:33Z","timestamp":1788570993269,"version":"build-2803163510"},"reference-count":177,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["11160380"],"award-info":[{"award-number":["11160380"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["1160227"],"award-info":[{"award-number":["1160227"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Melanoma is the most aggressive skin cancer, and in metastatic advanced states, it is completely refractory to chemotherapy. Therefore, it is relevant to understand the molecular bases that rule their aggressiveness. Connexins (Cxs) are proteins that under normal physiological conditions participate in intercellular communication, via the exchange of signaling molecules between the cytoplasm and extracellular milieu and the exchange of ions\/second messengers between the cytoplasm of contacting cells. These proteins have shown important roles in cancer progression, chemo\u2010 and radiotherapy resistance, and metastasis. Accordingly, Cx26 and Cx43 seem to play important roles in melanoma progression and metastasis. On the other hand, Cx46 is typically expressed in the eye lens, where it seems to be associated with oxidative stress protection in fiber lens cells. However, in the last decade, Cx46 expression has been associated with breast and brain cancers, due to its role in potentiation of both extracellular vesicle release and cancer stem cell\u2010like properties. In this review, we analyzed a potential role of Cx46 as a new biomarker and therapeutic target in melanoma.<\/jats:p>","DOI":"10.1111\/pcmr.12945","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T12:02:30Z","timestamp":1604404950000},"page":"853-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Connexins in melanoma: Potential role of Cx46 in its aggressiveness"],"prefix":"10.1111","volume":"34","author":[{"given":"Viviana P.","family":"Orellana","sequence":"first","affiliation":[{"name":"Universidad del Desarrollo. Centro de Fisiolog\u00eda Celular e Integrativa Clinica Alemana Facultad de Medicina Santiago Chile"},{"name":"Universidad del Desarrollo. Programa de Comunicaci\u00f3n Celular en C\u00e1ncer Cl\u00ednica Alemana Facultad de Medicina Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Tittarelli","sequence":"additional","affiliation":[{"name":"Programa Institucional de Fomento a la Investigaci\u00f3n Desarrollo e Innovaci\u00f3n (PIDi) Universidad Tecnol\u00f3gica Metropolitana (UTEM) Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2562-6686","authenticated-orcid":false,"given":"Mauricio A.","family":"Retamal","sequence":"additional","affiliation":[{"name":"Universidad del Desarrollo. Centro de Fisiolog\u00eda Celular e Integrativa Clinica Alemana Facultad de Medicina Santiago Chile"},{"name":"Universidad del Desarrollo. Programa de Comunicaci\u00f3n Celular en C\u00e1ncer Cl\u00ednica Alemana Facultad de Medicina Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0741-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.507228"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10050676"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.18569"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3984"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-03-2344"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13111"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25107"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1058-5"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0800815"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-016-0116-6"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00020"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01868459"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(01)00196-2"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2010.12.007"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb37657.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2011.02.003"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080803"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21952"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032531"},{"issue":"7","key":"e_1_2_8_23_1","first-page":"1487","article-title":"Purinergic control of AMPK activation by ATP released through connexin 43 hemichannels \u2010 pivotal roles in hemichannel\u2010mediated cell injury","volume":"127","author":"Chi Y.","year":"2014","journal-title":"Journal of Cell Science"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.5114\/pdia.2013.33376"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20246186"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15140"},{"issue":"9","key":"e_1_2_8_27_1","first-page":"887","article-title":"Update on the clinical use of kinase inhibitors in melanoma","volume":"15","author":"Cosgarea I.","year":"2017","journal-title":"JDDG \u2010 Journal of the German Society of Dermatology"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2004.11.013"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22554"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar3593"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021152709313"},{"key":"e_1_2_8_32_1","first-page":"309","article-title":"Cell motility affects the intensity of gap junctional coupling in prostate carcinoma and melanoma cell populations","volume":"33","author":"Daniel\u2010W\u00f3jcik A.","year":"2008","journal-title":"International Journal of Oncology"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1684\/ejd.2013.2060"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-019-5714-1"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/21.17.4085"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10701"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh191"},{"key":"e_1_2_8_38_1","volume-title":"Cancer Incidence, Mortality and Prevalence Worldwide","author":"Ferlay J.","year":"2002"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2012.12.006"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.383281"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1080\/cac.10.4-6.341.346"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11010102"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.560"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200409121"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.20"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.01084"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00626.2006"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1186-3"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.3109\/15419060109080727"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0426-6"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01067"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.6.11.1491"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80471-7"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1043-4682(10)80007-8"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05661"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.02.008"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2017.09.007"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.200407.x"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-009-0654-5"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.5A6719.2005"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2003.10.022"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.04.021"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184509"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.113.9.1535"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1816107116"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI8257"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgh208"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.06.007"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2004.10.001"},{"issue":"13","key":"e_1_2_8_70_1","first-page":"3558","article-title":"Posttranslational phosphorylation of lens fiber connexin46: A slow occurrence","volume":"34","author":"Jiang J. X.","year":"1993","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/15419060701402320"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(79)70018-1"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.36.22824"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25308"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020165"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep24799"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30872"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.02.025"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12213"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.05.008"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevOncog.v12.i3-4.30"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1177\/154411130201300107"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa407"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1593\/neo.10602"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2009.07.013"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.03.014"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-419X(79)90002-7"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1242\/bio.022251"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00034.2009"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.1.181"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100378"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.11.6949"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00374.2012"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504765200"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2007.04.080"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1006\/excr.2001.5357"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.03320"},{"issue":"2","key":"e_1_2_8_98_1","first-page":"156","article-title":"Expression of connexin 43 and E\u2010cadherin in choroidal melanoma","volume":"4","author":"Mou Y. Y.","year":"2011","journal-title":"International Journal of Ophthalmology"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.079"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8101175"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2019.00192"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/7651_2020_326"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.2174\/157488607781668837"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22608"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1093\/jrr\/rrs014"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11515-015-1381-z"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.3.C596"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00152.2015"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2012.01.017"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12860-016-0099-3"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.2"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2020.158705"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2042-07.2007"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00267"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00054.2009"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2010.09.004"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-3122"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00067.2017"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000166247.35992.dd"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020175"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000739"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00007.2003"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.8.2708"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2010.05.026"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22894"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-811X-12-31"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113578"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201010433"},{"issue":"4","key":"e_1_2_8_129_1","first-page":"572","article-title":"Survival rates of patients with metastatic malignant melanoma","volume":"7","author":"Sandru A.","year":"2014","journal-title":"Journal of Medicine and Life"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e318278d401"},{"issue":"1","key":"e_1_2_8_131_1","first-page":"95","article-title":"Regional growth of different human melanomas as metastases in the brain of nude mice","volume":"136","author":"Schackert G.","year":"1990","journal-title":"The American Journal of Pathology"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00015.2010"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr103"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.37"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.212506"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.389"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206454"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9041040"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmq047"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051428"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37221-2"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.112748"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109902200"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2744(200006)28:2<119::AID-MC8>3.0.CO;2-N"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-013-9580-z"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112541"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-02938-1"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.162"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.651547"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301297"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207567"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.05.065"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19041159"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0095"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbiomolbio.2020.03.002"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11060845"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188380"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-0300"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.211"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2397"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22049"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182495"},{"key":"e_1_2_8_163_1","first-page":"965","article-title":"Suppression of connexin 43 expression by miR\u2010106a promotes melanoma cell proliferation","volume":"23","author":"Wang J. L.","year":"2019","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7400757"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.00984.x"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709684"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00596"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-019-0497-x"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13655"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067662"},{"key":"e_1_2_8_171_1","first-page":"245","article-title":"Role of cell\u2010cell communication in tumor suppression","volume":"51","author":"Yamasaki H.","year":"1990","journal-title":"Immunology Series"},{"key":"e_1_2_8_172_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.30889"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-09-03588.2003"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-440X(96)80073-X"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-05227-2"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305072200"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.01.001"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24235"}],"container-title":["Pigment Cell &amp; Melanoma Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12945","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/pcmr.12945","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/pcmr.12945","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T03:08:31Z","timestamp":1693278511000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/pcmr.12945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,20]]},"references-count":177,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1111\/pcmr.12945"],"URL":"https:\/\/doi.org\/10.1111\/pcmr.12945","archive":["Portico"],"relation":{},"ISSN":["1755-1471","1755-148X"],"issn-type":[{"value":"1755-1471","type":"print"},{"value":"1755-148X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,20]]},"assertion":[{"value":"2020-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}