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Its pathophysiology has gathered the attention of researchers for years, and many advances have been made in the clarification of the interaction between different factors that result in depigmented macule formation. The complex interplay between non\u2010immunological and immunological factors in vitiligo is key for the development of the disease, and the participation of cells other than melanocytes, such as keratinocytes, fibroblasts, natural killer cells, and innate lymphoid cells, has been shown. Recent advances have also brought to the understanding of the complex part played by a specific subtype of T cells: T\u2010resident memory cells. This review analyzes some of the most recent insights in vitiligo pathogenesis underlining the interactions between different cell types, which are the basis for the therapeutic approaches under development.<\/jats:p>","DOI":"10.1111\/pcmr.12949","type":"journal-article","created":{"date-parts":[[2020,12,5]],"date-time":"2020-12-05T11:44:56Z","timestamp":1607168696000},"page":"236-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":128,"title":["An update on Vitiligo pathogenesis"],"prefix":"10.1111","volume":"34","author":[{"given":"Julien","family":"Seneschal","sequence":"first","affiliation":[{"name":"INSERM U1035 Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers (BMGIC) Immunodermatology ATIP\u2010AVENIR University of Bordeaux FHU ACRONIM Bordeaux France"},{"name":"Department of Dermatology and Pediatric Dermatology and National Reference Center for Rare Skin Disorders H\u00f4pital Saint\u2010Andr\u00e9 Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Boniface","sequence":"additional","affiliation":[{"name":"INSERM U1035 Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers (BMGIC) Immunodermatology ATIP\u2010AVENIR University of Bordeaux FHU ACRONIM Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0669-1442","authenticated-orcid":false,"given":"Andrea","family":"D\u2019Arino","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute IRCCS Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4899-6639","authenticated-orcid":false,"given":"Mauro","family":"Picardo","sequence":"additional","affiliation":[{"name":"San Gallicano Dermatological Institute IRCCS Rome 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