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In humans, skin pigmentation plays a part in sun protection. Skin pigmentation depends on the ratio of the two pigments pheomelanin and eumelanin, both synthesized by a specialized cell population, the melanocytes. In this review, we explore one important factor in pigmentation: the <jats:italic>tyrosinase\u2010related protein 1<\/jats:italic> (<jats:italic>TYRP1<\/jats:italic>) gene which is involved in eumelanin synthesis via the TYRP1 protein. Counterintuitively, high <jats:italic>TYRP1<\/jats:italic> mRNA expression is associated with a poor clinical outcome for patients with metastatic melanomas. Recently, we were able to explain this unexpected <jats:italic>TYRP1<\/jats:italic> function by demonstrating that <jats:italic>TYRP1<\/jats:italic> mRNA sequesters microRNA\u201016, a tumor suppressor miRNA. Here, we focus on actors influencing <jats:italic>TYRP1<\/jats:italic> mRNA abundance, particularly transcription factors, single nucleotide polymorphisms (SNPs), and miRNAs, as they all dictate the indirect oncogenic activity of <jats:italic>TYRP1<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/pcmr.12951","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T09:23:32Z","timestamp":1607678612000},"page":"836-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Human <i>TYRP1<\/i>: Two functions for a single gene?"],"prefix":"10.1111","volume":"34","author":[{"given":"Arthur","family":"Gautron","sequence":"first","affiliation":[{"name":"CNRS IGDR (Institut de g\u00e9n\u00e9tique et d\u00e9veloppement de Rennes) \u2013 UMR 6290, F\u201035000 Univ. 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