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Currently, robust and reliable biomarker to predict response and\/or occurrence of irAEs to ICI are missing. Herein, we wanted to explore whether germline variants (SNPs) could predict the clinical outcomes of melanoma patients treated with ICIs. We performed a whole exome sequencing using gDNA isolated from blood, from a discovery cohort of 57 patients with metastatic melanoma. The top associations were then tested in a validation cohort of 57 patients. Our work suggests that individual germline genetic variants have no or weak impact on the response to ICIs. Only, variants in IL1RL1 have a significant impact in treatment response. The role of IL1RL1 in the immune response against melanoma and as a theranostic marker warrants further investigations.<\/jats:p>","DOI":"10.1111\/pcmr.12958","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T00:15:03Z","timestamp":1610756103000},"page":"978-983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Germline variants in exonic regions have limited impact on immune checkpoint blockade clinical outcomes in advanced melanoma"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0528-4829","authenticated-orcid":false,"given":"Henri","family":"Montaudi\u00e9","sequence":"first","affiliation":[{"name":"Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M) Universit\u00e9 Nice C\u00f4te d'Azur INSERM Nice France"},{"name":"Department of Dermatology Universit\u00e9 Nice C\u00f4te d'Azur, CHU Nice Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8770-864X","authenticated-orcid":false,"given":"Guillaume Emmanuel","family":"Beranger","sequence":"additional","affiliation":[{"name":"Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M) Universit\u00e9 Nice C\u00f4te d'Azur INSERM Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Reinier","sequence":"additional","affiliation":[{"name":"Biology and Pathologies of Melanocytes Universit\u00e9 Nice C\u00f4te d'Azur Team 1, Inserm U1065 Equipe labellis\u00e9e ARC 2015, C3M Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Nottet","sequence":"additional","affiliation":[{"name":"Biology and Pathologies of Melanocytes Universit\u00e9 Nice C\u00f4te d'Azur Team 1, Inserm U1065 Equipe labellis\u00e9e ARC 2015, C3M Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universit\u00e9 Nice C\u00f4te d'Azur, CHU Nice Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Picard\u2010Gauci","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universit\u00e9 Nice C\u00f4te d'Azur, CHU Nice Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Troin","sequence":"additional","affiliation":[{"name":"Department of Dermatology Universit\u00e9 Nice C\u00f4te d'Azur, CHU Nice Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Ballotti","sequence":"additional","affiliation":[{"name":"Biology and Pathologies of Melanocytes Universit\u00e9 Nice C\u00f4te d'Azur Team 1, Inserm U1065 Equipe labellis\u00e9e ARC 2015, C3M Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0797-6570","authenticated-orcid":false,"given":"Thierry","family":"Passeron","sequence":"additional","affiliation":[{"name":"Centre M\u00e9diterran\u00e9en de M\u00e9decine Mol\u00e9culaire (C3M) Universit\u00e9 Nice C\u00f4te d'Azur INSERM Nice France"},{"name":"Department of Dermatology Universit\u00e9 Nice C\u00f4te d'Azur, CHU Nice Nice France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,24]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.02.010"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000271"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30406-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-2267"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI67119"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2020.03.943"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910836"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19092676"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.95"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/thg.2014.79"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301785"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2019-0674"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-020-00729-2"}],"container-title":["Pigment Cell &amp; 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