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In this study, effect of lenalidomide was checked on the development of vitiligo lesions, level of various cytokines, and T lymphocytes in the mouse model. The vitiligo mouse model was developed by immunizing C57BL\/6 mouse with anti\u2010mouse tyrosine\u2010related protein 2. Lenalidomide was orally given to mice daily, and the effect was observed on the development of vitiligo lesions. The level of T lymphocytes in blood was checked by flow cytometry. Serum cytokine levels were checked by enzyme\u2010linked immunosorbent assay. Vitiligo lesions were found significantly smaller in lenalidomide\u2010treated mice models. It significantly decreased the serum levels of IFN\u2010\u03b3, TNF\u2010\u03b1, IL\u20101\u03b2, and IL\u20106 but elevated the levels of IL\u20104 and IL\u201010. It non\u2010significantly elevated CD4<jats:sup>+<\/jats:sup>\/CD8<jats:sup>+<\/jats:sup> T\u2010cell ratio. Lenalidomide had an inhibitory effect on the development of vitiligo lesions in mice models by suppressing the serum level of pro\u2010inflammatory cytokines and increasing anti\u2010inflammatory cytokine levels. It modulated the immune response in vitiligo mice models toward an anti\u2010inflammatory profile suggesting its use in the management of vitiligo.<\/jats:p>","DOI":"10.1111\/pcmr.12962","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T13:09:22Z","timestamp":1612184962000},"page":"918-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Immune\u2010modulatory effects of lenalidomide inhibited the progression of lesions in a vitiligo mouse model"],"prefix":"10.1111","volume":"34","author":[{"given":"Naveed","family":"Pervaiz","sequence":"first","affiliation":[{"name":"Department of Zoology Panjab University Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harjot","family":"Kaur","sequence":"additional","affiliation":[{"name":"Department of Zoology Panjab University Chandigarh 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