{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:18:24Z","timestamp":1789010304380,"version":"build-2803163510"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,3,17]],"date-time":"2021-03-17T00:00:00Z","timestamp":1615939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R35CA220481"],"award-info":[{"award-number":["1R35CA220481"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with non\u2010supernumerary ring chromosome 7 syndrome have an increased incidence of hemangiomas, caf\u00e9\u2010au\u2010lait spots, and melanocytic nevi. The mechanism for the increased incidence of these benign neoplasms is unknown. We present the case of a 22\u2010year\u2010old man with ring chromosome 7 and multiple melanocytic nevi. Two nevi, one on the right ear and the other on the right knee, were biopsied and diagnosed as desmoplastic Spitz nevi. Upon targeted next\u2010generation DNA sequencing, both harbored <jats:italic>BRAF<\/jats:italic> fusions. Copy number alterations and fluorescence in situ hybridization (FISH) for <jats:italic>BRAF<\/jats:italic> suggested that the fusions arose on the ring chromosome 7. Hence, one reason for increased numbers of nevi in patients with non\u2010supernumerary ring chromosome 7 syndrome may be increased likelihood of BRAF fusions, due to the instability of the ring chromosome.<\/jats:p>","DOI":"10.1111\/pcmr.12963","type":"journal-article","created":{"date-parts":[[2021,2,1]],"date-time":"2021-02-01T13:28:08Z","timestamp":1612186088000},"page":"987-993","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Multiple desmoplastic Spitz nevi with BRAF fusions in a patient with ring chromosome 7 syndrome"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5444-0349","authenticated-orcid":false,"given":"Simon F.","family":"Roy","sequence":"first","affiliation":[{"name":"Department of Pathology University of Montr\u00e9al Montr\u00e9al OC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1836-6062","authenticated-orcid":false,"given":"Boris C.","family":"Bastian","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California in San Francisco San Francisco CA USA"},{"name":"Department of Pathology University of California in San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheilagh","family":"Maguiness","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Giubellino","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota Minneapolis MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swapna S.","family":"Vemula","sequence":"additional","affiliation":[{"name":"Department of Pathology University of California in San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy H.","family":"McCalmont","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California in San Francisco San Francisco CA USA"},{"name":"Department of Pathology University of California in San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3941-3561","authenticated-orcid":false,"given":"Iwei","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of California in San Francisco San Francisco CA USA"},{"name":"Department of Pathology University of California in San Francisco San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.8.2.18"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000761"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.09.009"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12148"},{"key":"e_1_2_8_6_1","volume-title":"WHO Classification of Skin Tumours (4th Edition)","author":"Elder D. 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