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There are non\u2010syndromic and syndromic types of OCA, depending on whether the gene product affected impairs essentially the function of melanosomes or, in addition, that of other lysosome\u2010related organelles (LROs), respectively. Syndromic OCA can be more severe and associated with additional systemic consequences, beyond pigmentation and vision alterations. In addition to OCA, albinism can also be presented without obvious skin and hair pigmentation alterations, in ocular albinism (OA), and a related genetic condition known as foveal hypoplasia, optic nerve decussation defects, and anterior segment dysgenesis (FHONDA). In this review, we will focus only in the genetics of skin pigmentation in OCA, both in human and mouse, updating our current knowledge on this subject.<\/jats:p>","DOI":"10.1111\/pcmr.12982","type":"journal-article","created":{"date-parts":[[2021,5,8]],"date-time":"2021-05-08T20:26:01Z","timestamp":1620505561000},"page":"786-799","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Genetics of non\u2010syndromic and syndromic oculocutaneous albinism in human and mouse"],"prefix":"10.1111","volume":"34","author":[{"given":"Almudena","family":"Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology National Centre for Biotechnology (CNB\u2010CSIC) Madrid Spain"},{"name":"CIBERER\u2010ISCIII Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1674-4093","authenticated-orcid":false,"given":"Masahiro","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gema","family":"Garrido","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology National Centre for Biotechnology (CNB\u2010CSIC) Madrid Spain"},{"name":"CIBERER\u2010ISCIII Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Montero","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology National Centre for Biotechnology (CNB\u2010CSIC) Madrid Spain"},{"name":"CIBERER\u2010ISCIII Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Guardia","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology National Centre for Biotechnology (CNB\u2010CSIC) Madrid Spain"},{"name":"CIBERER\u2010ISCIII Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4669-9721","authenticated-orcid":false,"given":"Tamio","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yamagata University Faculty of Medicine Yamagata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3941-1176","authenticated-orcid":false,"given":"Lluis","family":"Montoliu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology National Centre for Biotechnology (CNB\u2010CSIC) Madrid Spain"},{"name":"CIBERER\u2010ISCIII Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,8]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.02.053"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102015\u201009\u2010671636"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.04543"},{"issue":"6","key":"e_1_2_15_5_1","first-page":"1145","article-title":"Mutation in and lack of expression of tyrosinase\u2010related protein\u20101 (TRP\u20101) in melanocytes from an individual with brown oculocutaneous albinism: A new subtype of albinism classified as \u201cOCA3\u201d","volume":"58","author":"Boissy R. 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