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In areas that are frequently exposed to the sun, photoaging blends with the process of intrinsic aging, resulting in an increased senescent cells number and consequently accelerating the aging process. The severity of photodamage depends on constitutional factors, including skin phototype (skin color, tanning capacity), intensity, and duration of sunlight\/UV exposure. Aging affects nearly every aspect of cutaneous biology, including pigmentation. Clinically, the phenotype of age pigmented skin has a mottled, uneven color, primarily due to age spots, with or without hypopigmentation. Uneven pigmentation might be attributed to the hyperactivation of melanocytes, altered distribution of pigment, and turnover. In addition to direct damage to pigment\u2010producing cells, photodamage alters the physiological crosstalk between keratinocytes, fibroblasts, endothelial cells, and melanocytes responsible for natural pigmentation homeostasis. Interestingly, age\u2010independent diffuse expression of senescence\u2010associated markers in the dermal and epidermal compartment is also associated with vitiligo, suggesting that premature senescence plays an important role in the pathology.<\/jats:p>","DOI":"10.1111\/pcmr.12994","type":"journal-article","created":{"date-parts":[[2021,5,28]],"date-time":"2021-05-28T13:23:31Z","timestamp":1622208211000},"page":"800-813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Alterations of the pigmentation system in the aging process"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8697-4292","authenticated-orcid":false,"given":"Hee Young","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Dermatology Ajou University School of Medicine  Suwon 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