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As a protective response, the skin has inbuilt defense mechanisms, including DNA repair, cell cycle, apoptosis, and melanin synthesis. Though DNA repair, cell cycle, and apoptosis are clock controlled, the circadian mechanisms associated with melanin synthesis are not well understood. Using human melanocytes and melanoma cells under synchronized clock conditions, we observed that the microphthalmia\u2010associated transcription factor (MITF), a rate\u2010limiting protein in melanin synthesis, is expressed rhythmically with 24\u2010hr periodicity in the presence of circadian clock protein, BMAL1. Furthermore, we demonstrated that BMAL1 binds to the promoter region of <jats:italic>MITF<\/jats:italic> and transcriptionally regulates its expression, which positively influences melanin synthesis. Finally, we report that an increase in melanin levels due to BMAL1 overexpression protects human melanoma cells from UVB. In conclusion, our studies provide novel insights into the mechanistic role of the circadian clock in melanin synthesis and protection against UVB\u2010mediated DNA damage and genomic instability.<\/jats:p>","DOI":"10.1111\/pcmr.12998","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T14:35:48Z","timestamp":1624458948000},"page":"955-965","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Circadian clock protein BMAL1 regulates melanogenesis through <i>MITF<\/i> in melanoma cells"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8120-9487","authenticated-orcid":false,"given":"Soumyadeep","family":"Sarkar","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy and Pharmaceutical Sciences Washington State University Spokane WA USA"},{"name":"Sleep and Performance Research Center Washington State University Spokane WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3644-1011","authenticated-orcid":false,"given":"Kenneth I.","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy and Pharmaceutical Sciences Washington State University Spokane WA USA"},{"name":"Sleep and Performance Research Center Washington State University Spokane WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3534-7744","authenticated-orcid":false,"given":"Panshak P.","family":"Dakup","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy and Pharmaceutical Sciences Washington State University Spokane WA USA"},{"name":"Sleep and Performance Research Center Washington State University Spokane WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendra P.","family":"Gajula","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences College of Pharmacy and Pharmaceutical Sciences Washington State University Spokane WA USA"},{"name":"Sleep and Performance Research Center Washington State University Spokane WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4457-093X","authenticated-orcid":false,"given":"Bala S. 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