{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:13:33Z","timestamp":1792034013973,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,8,23]],"date-time":"2021-08-23T00:00:00Z","timestamp":1629676800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pigment Cell Melanoma Res"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The WHO classification identifies nine classes of melanocytic proliferations according to location, UV exposure, histological, and genetic features. Only a minority of lesions remain unclassified. We describe five cases that harbored either an\n                    <jats:italic>ERBIN\u2010RASGRF2<\/jats:italic>\n                    or an\n                    <jats:italic>ATP2B4\u2010RASGRF2<\/jats:italic>\n                    in\u2010frame fusion transcript. These lesions were collected from different studies, unified only by the lack of identifiable known mutations, with a highly variable phenotype. One case was a large abdominal congenital nevus, three were slowly growing pigmented nodules, and the last was an ulcerated nodule arising on the site of a preexisting small nevus, known since childhood. The latter was diagnosed as a 4\u00a0mm thick melanoma with loss of BAP1 expression. The four other cases were compound, melanocytic proliferations with an unusual deep pattern of small dense nests of bland melanocytes encased in a fibrous background. The\n                    <jats:italic>RASGRF2<\/jats:italic>\n                    fusion was confirmed by a break\u2010apart FISH technique. Array CGH performed in three cases found non\u2010recurrent secondary copy number alterations. Follow\u2010up was uneventful. In silico analysis identified a single\n                    <jats:italic>RASGRF2<\/jats:italic>\n                    fusion in the TCGA pan\u2010cancer database, whereas\n                    <jats:italic>RASGRF2<\/jats:italic>\n                    variants were stochastically distributed in all cancer subtypes.\n                  <\/jats:p>","DOI":"10.1111\/pcmr.13004","type":"journal-article","created":{"date-parts":[[2021,7,26]],"date-time":"2021-07-26T11:06:51Z","timestamp":1627297611000},"page":"1074-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["RASGRF2 gene fusions identified in a variety of melanocytic lesions with distinct morphological features"],"prefix":"10.1111","volume":"34","author":[{"given":"Aur\u00e9lie","family":"Houlier","sequence":"first","affiliation":[{"name":"University of Lyon Universit\u00e9 Claude Bernard Lyon 1 CNRS UMR 5286 INSERM U1052 Cancer Research Centre of Lyon Lyon France"},{"name":"Department of Biopathology Centre L\u00e9on B\u00e9rard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pissaloux","sequence":"additional","affiliation":[{"name":"University of Lyon Universit\u00e9 Claude Bernard Lyon 1 CNRS UMR 5286 INSERM U1052 Cancer Research Centre of Lyon Lyon France"},{"name":"Department of Biopathology Centre L\u00e9on B\u00e9rard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4731-7817","authenticated-orcid":false,"given":"Franck","family":"Tirode","sequence":"additional","affiliation":[{"name":"University of Lyon Universit\u00e9 Claude Bernard Lyon 1 CNRS UMR 5286 INSERM U1052 Cancer Research Centre of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00e9mie","family":"Lopez Ramirez","sequence":"additional","affiliation":[{"name":"University of Lyon Universit\u00e9 Claude Bernard Lyon 1 CNRS UMR 5286 INSERM U1052 Cancer Research Centre of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Plaschka","sequence":"additional","affiliation":[{"name":"University of Lyon Universit\u00e9 Claude Bernard Lyon 1 CNRS UMR 5286 INSERM U1052 Cancer Research Centre of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Caramel","sequence":"additional","affiliation":[{"name":"University of Lyon Universit\u00e9 Claude Bernard Lyon 1 CNRS UMR 5286 INSERM U1052 Cancer Research Centre of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Masse","sequence":"additional","affiliation":[{"name":"University of Lyon Universit\u00e9 Claude Bernard Lyon 1 CNRS UMR 5286 INSERM U1052 Cancer Research Centre of Lyon Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2251-8241","authenticated-orcid":false,"given":"Arnaud","family":"de la Fouchardiere","sequence":"additional","affiliation":[{"name":"University of Lyon Universit\u00e9 Claude Bernard Lyon 1 CNRS UMR 5286 INSERM U1052 Cancer Research Centre of Lyon Lyon France"},{"name":"Department of Biopathology Centre L\u00e9on B\u00e9rard Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,23]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.195"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.2524"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12785"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700490"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2271"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0095"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.1020140503"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000902"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000568"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700725"},{"key":"e_1_2_13_12_1","volume-title":"WHO Classification of Skin Tumours","author":"Elder D. 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