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The specific mechanisms underlying vitiligo have not been fully understood. As a result, treating vitiligo is a dermatological challenge. Recently, much attention has been paid to the dysfunction and interaction of organelles under environmental stress. The impaired organelles could generate misfolded proteins, particularly accumulated toxic premelanosome protein (PMEL) amyloid oligomers, activating the autoimmune system and cause melanocyte damage. Unfolded protein response (UPR) dysfunction accelerates toxic PMEL accumulation. Herein, we presented a narrative review on UPR\u2019s role in vitiligo, the misfolded PMEL\u2010induced attack of the autoimmune system under autophagy dysfunction caused by abnormal activation of transient receptor potential (TRP) channels and the background of UPR system defects in melanocytes. All of these mechanisms were integrated to form UPR\/PMEL\u2010TRP channels\/autophagy axis, providing a new understanding of vitiligo pathogenesis.<\/jats:p>","DOI":"10.1111\/pcmr.13006","type":"journal-article","created":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T17:15:03Z","timestamp":1627838103000},"page":"6-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The impaired unfolded protein\u2010premelanosome protein and transient receptor potential channels\u2010autophagy axes in apoptotic melanocytes in vitiligo"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9374-863X","authenticated-orcid":false,"given":"Bo","family":"Xie","sequence":"first","affiliation":[{"name":"Departement of Dermatology Hangzhou Third People's Hospital Affiliated Hangzhou Dermatology Hospital Zhejiang University School of Medicine Hangzhou 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