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Furthermore, TRP\u20101 and c\u2010Kit expression disappeared and EGFR receptor and nestin expression were induced in the cells. Here, we further characterized the phenotype of these dedifferentiated cells and by comparing them to mature pigmented melanocytes we detected crucial steps in their phenotype change. Our data suggest that normal adult melanocytes easily dedifferentiate into pluripotent stem cells given the right environment. This dedifferentiation process described here for normal melanocyte is very similar to what has been described for melanoma cells, indicating that phenotype switching driven by environmental factors is a general characteristic of melanocytes that can occur independent of malignant transformation.<\/jats:p>","DOI":"10.1111\/pcmr.13012","type":"journal-article","created":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T02:09:32Z","timestamp":1630462172000},"page":"38-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Phenotypic plasticity of melanocytes derived from human adult skin"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5422-7812","authenticated-orcid":false,"given":"D\u00e1niel L\u00e1szl\u00f3","family":"Vid\u00e1cs","sequence":"first","affiliation":[{"name":"Department of Dermatology and Allergology University of Szeged Szeged 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