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Although YAP and TAZ have shown redundancy in many contexts, it is still unknown whether or not this is true in melanoma. Here, we show that while both YAP and TAZ are expressed in a panel of melanoma cell lines, depletion of YAP results in decreased cell numbers, focal adhesions, and the ability to invade matrigel. Using non\u2010biased RNA\u2010sequencing analysis, we find that melanoma cells depleted of YAP, TAZ, or YAP\/TAZ exhibit drastically different transcriptomes. We further uncover the ARP2\/3 subunit ARPC5 as a specific target of YAP but not TAZ and that ARPC5 is essential for YAP\u2010dependent maintenance of melanoma cell focal adhesion numbers. 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